レプラ
Online ISSN : 2185-1352
Print ISSN : 0024-1008
ISSN-L : 0024-1008
21 巻, 6 号
選択された号の論文の7件中1~7を表示しています
  • 第4篇 鼠癩菌死菌ワクチンによる白鼠の鼠癩感染防禦実驗
    谷村 保夫
    1952 年 21 巻 6 号 p. 217-224
    発行日: 1952/11/20
    公開日: 2008/06/30
    ジャーナル フリー
    1) The vaccine of heat killed murine leprosy bacilli inhibits the onset of leproma in the inoculated site to some extent, but not the lesions in the viscera.
    2) The liquid paraffine vaccine of murine bacilli not only prolongs the initiation of the leproma, but also prevents the growth of the organisms in the lymph nodes or in the viscera.
    3) The liquid paraffine vaccine of the nonpathogenic acid-fasts No 16, prolongs the onset of leproma, but is not strong enough to give any influence on the occurrence of visceral changes.
    4) The immunologic intensities of the three vaccines abovementioned can be arranged in the descending order as following; the liquid paraffine vaccine of the murine bacilli, the heat killed vaccine of the murine bacilli and the liquid paraffine vaccine of the nonpathogenic acid-fast.
  • 第5篇 白鼠の鼠癩に於けるコッホ
    谷村 保夫
    1952 年 21 巻 6 号 p. 225-230
    発行日: 1952/11/20
    公開日: 2008/06/30
    ジャーナル フリー
    1) The reinoculation of the murine bacillus on the animals infected with the same organisms is unable to produce leproma easily. From this fact, it can be seen that the superinfection can hardly take place in murine leprosy.
    2) The skin reaction (Koch's phenomenon) can not be observed in the inoculated site with live murine leprosy bacillus.
  • 其の2 皮下、睾丸内、腦内及び静脈内接種法における増殖態度
    中村 昌弘, 志方 弘之, 新宮 正久
    1952 年 21 巻 6 号 p. 231-233
    発行日: 1952/11/20
    公開日: 2008/06/30
    ジャーナル フリー
    Subcutaneous inoculation gave rise to the severest lesions in the inoculated site, but the individual variations of animals caused marked differences in some of the initiations of the disease. By intra-testis inoculation the disease developed favorably all without distinction. Intracerebral injection caused the similar progress as intratestis inoculation. And intravenous injection is not suitable for the deveiopment of the disease.
  • 其の3 鼠癩菌の生体内Slide culture法の試み
    中村 昌弘
    1952 年 21 巻 6 号 p. 234-236
    発行日: 1952/11/20
    公開日: 2008/06/30
    ジャーナル フリー
    The cover glasses were smeared with murine bacilli, put under skin of intact white rats and taken away at the desired intervals to examine the multiplication of the bacilli on the surface of them. In some favorable cases the fission of bacilli was recognized after a week, and globi were formed after four weeks. The multiplication was carried out in the same way as the otner acid-fasts.
  • 第二篇 小兒癩
    難波 政士, 藤原 弘
    1952 年 21 巻 6 号 p. 237-239
    発行日: 1952/11/20
    公開日: 2008/06/30
    ジャーナル フリー
    The examination of serum protein fractions in leprous cnildren by Tiselius's eiectrophoresis presented the same changes in adults mentioned in the previous report, tnough the increase of γ-globulin was not so remarkable in children as in adults.
  • 平井 輝一
    1952 年 21 巻 6 号 p. 240-250
    発行日: 1952/11/20
    公開日: 2008/06/30
    ジャーナル フリー
    (Part I) HISTOLOGICAL LESIONS IN THE NASAL CAVITY AND TEETH
    Histological examination of the outer part of the nose and upper jaw of the severely infected animals presented the lesions in 51% of the nasal mucous membrane and 18% of the tooth pulp. The lesions were developing hematogenously along the connective tissue in the nose, as well as in the teeth, where they appeared more frequently and remarkably in the marrow of the alveoles and in the periodontium than the tooth pulp. From these results, it is supposed that the high frequency of lesions in the tooth pulp in human leprosy is due to the invasion of the bacilli along the nervous fibers.
    (Part II) LESIONS AFTER INOCULATION THROUGH NASAL CAVITY AND TOOTH GUM
    After the bacilli were rubbed in through nasal mucous membrane or the tooth gum, lesions appeared in higher percentages in the regional lymph nodes or the organs, such as the spleen or liver, rich in the reticuloendothelial tissue, than the local site, where slight lesions were found in very few cases. As the nasal mucous membrane is not the preditected site of murine leprosy, no primary lesion occurs even when the bacilli intrude there. And it seems possible that when the human bacillus infects the nasal mucous membrane, it can produce the primary lesion there.
    (Part III) SUPPLEMENT TO THE DERIVATION OF THE MURINE LEPRA CELLS
    The vital staining of trypan blue into the murine lesions of the lymph nodes informs us of the derivation of murine lepra cells from the histiocytes. The intraperitoneal inoculation of the bacilli shows that the wandering monocytes, although they have the phagocytosing power, do not permit the multiplication, while the phagocytic cells fixed in the tissue allow the multiplication of bacilli and transformed into lepra cells.
  • 西村 眞二, 谷村 保夫, 高橋 竹代, 大島 新之助
    1952 年 21 巻 6 号 p. 251-253
    発行日: 1952/11/20
    公開日: 2008/06/30
    ジャーナル フリー
    No favorable effect was recognized in the treatment of murine leprosy with Shwart zman's filtrate. The multiplied efficacy of the combinated treatment of promin and Shwartzman's filtrate was not observed. From these facts, Shwartzman's filtrate can not be expected in the treatment of human leprosy.
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