巻号一覧
後続誌
26 巻 (1957)
- 6 号 p. 297-
- 5 号 p. 227-
- 3 号 p. 117-
- 2 号 p. 49-
- 1 号 p. 1-
26 巻, 1 号
選択された号の論文の7件中1～7を表示しています
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第3報 トリプシン消化感染皮下組織より集菌した 菌体の構成成分について中村 昌弘1957 年 26 巻 1 号 p. 1-7
発行日: 1957/01/20
公開日: 2008/06/30
ジャーナル フリーThe intact murine leprosy bacilli are obtained from the subcutaneous tissues of rats infectedwith murine leprosy bacilli by trypsin digestion before the Hanks' method which is the modification of mitochondria concentration.
The results of analysis for the fundamental chemical compositions of the murine leprosy bacilli obtained in intact and pure form are as follows:
Compared with other cultivable acid-fast bacilli, total nitrogen, carbohydrate and nucleic acid are somewhat less, and alcohol-ether extractable substances and phospholipid are more. Consequently, the values of chemical compositions of the bacilli described in the preceeding papers were somewhat corrected. Moreover, the separation method of the intact bacilli using trypsin digestion before the Hanks' method may contribute toward the preparation of lepromin antigen.抄録全体を表示PDF形式でダウンロード (641K) -
高山 保郎1957 年 26 巻 1 号 p. 8-14
発行日: 1957/01/20
公開日: 2008/06/30
ジャーナル フリー500γ or 150γ (3times) of X-ray had been irradiated generally before the inoculation of murine leprosy bacillus, then 0.25mg. of Cortisone was intramuscularly injected every other day. Or after infection 0.25mg. of Cortisone was intramuscularly injected on alternate days. Or the murine leprosy suspension added with Toluidinblue (1mg./cc.), Toluidinblue alum, egg yellow solution (25%) and the mixture of ox-serum albumin and ferment extract (2%)was inoculated.
The following results were obtained.
(1) Toluidinblue and that mixed with alum have no ability to accelerate the onset of murine leprosy.
(2) Cortisone administration after X-ray irradiation or administration of Cortisone alone suppress the murine leprous granulation to some extent.
(3) Egg yellow or the mixture of ox-serum albumin and ferment extract added with murine leprosy bacillus have some effect accelerating the granulation of murine leprosy.抄録全体を表示PDF形式でダウンロード (470K) -
高山 保郎1957 年 26 巻 1 号 p. 15-18
発行日: 1957/01/20
公開日: 2008/12/10
ジャーナル フリー25 of female white rats were divided in 5 groups. Group I was used as DDS inhibitorygroup, Group II DDS treatment, Group III Promin inhibitory, Group IV Promin treatmentand Group V the control. In inhibitory experiments, from the next day of inoculation DDSof 0.1 mg. was injected 6 days in a week to the 7 th week and 0.2 mg. to the 13 th weekand 0.4 mg. to the 22 th week. By administration of Promin, since the next day 45 mg. wasinjected through the tailvein twice a week to the 22 th week. With the treatment experiment, 4 weees after inoculation elapsed and then animals received the DDS and Promin in the samemanner as the inhibitory experiments.
As the results, intramusculary DDS seems to be inferior to Promin both in the adminis-tration method and doses used in this experiments.抄録全体を表示PDF形式でダウンロード (387K) -
牛尾 喜一, 高山 保郎, 池田 一馬1957 年 26 巻 1 号 p. 19-23
発行日: 1957/01/20
公開日: 2008/12/10
ジャーナル フリーThe size of murine lepromas and the distribution of bacilli in the rat body were examinedupon experimental murine leprosy after administration of Isonicotinyl-3-methoxy-4-hydroxy-benzal hydrazone, 4: 4'-diamino diphenyl sulfoxide and Neo-minophagen AT, by means ofjudgement of inhibitory and treatment effects of these 3 drugs.
As the results, it is known that Isonicotinyl-3-methoxy-4- hydroxybenzal hydrazone hasstriking effect both in inhibition and treatment, while, 4:4'-diamino diphenyl sulfoxide andNeo-minophagen AT have a small inhibitory effects, which could not be expected thera-peutically by the doses used in this experiment.抄録全体を表示PDF形式でダウンロード (553K) -
北川 敏夫, 永田 高見, 井手 二郎1957 年 26 巻 1 号 p. 24-29
発行日: 1957/01/20
公開日: 2008/12/10
ジャーナル フリーWith the advance of chemotherapy of leprosy, the necessity of surgical treatment is in-creasing. To resolve the problem of supplying the artificial legs to the amputated patients in Kikuchi-Keifuen, statistical conditions of patients and the biological examinations of amputated ends were examined.
The results are as following:
Total patients examined were 114. Amputation of both legs were 33; neural type 71 (male 47 and female 24) and lepromatous type 43 (male 24 and female 19).
(1) Malum perforans pedis is the cause of amputation in most neural and lepromatous patients.
(2) In most cases amputation was carried out in the middle or a lower third part.
(3) In a half cases, the patients complained of neuralgia, pressure or knock pains.
(4) In a half cases, the amputated ends underwent ulcer.
(5) In leprosy patients the development of the muscles due to prothesis was not observed and atrophy of the muscles was remarkable. The consistence of the muscles are 0 in 15 (31.8 %) and the average 5.6 and 0 in 14 (43.0%) and the average 5.6 of 32 lepromatous patients. In both types the consistence remarkably decreases.
(6) The regular decrease of temperature of the amputated ends were not observed. In lepromatous type the average 3.7°C decrease was observed compared with non-amputated side.
(7) By Wade-Takagaki method, attention should be paid to perspiration in the amputated ends.
(8) By X-ray examination the changes are not simple and consist of variations.抄録全体を表示PDF形式でダウンロード (748K) -
A. Hansen, C. Looft1957 年 26 巻 1 号 p. 30-34
発行日: 1957/01/20
公開日: 2008/06/30
ジャーナル フリーPDF形式でダウンロード (509K) -
菅井 健治, 福士 勝成, 川津 邦雄1957 年 26 巻 1 号 p. 34-38
発行日: 1957/01/20
公開日: 2008/12/10
ジャーナル フリーPDF形式でダウンロード (723K)
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