To evaluate the relationship between the development of plantar ulcer and nerve damage, the plantar region was histologically examined in the denervated animal due tothe desection of sciatic nerve.After denervation, the arteriolar lesions were developed in the early stage of secondweek in leg, foot-back and sole, and they were devided into the four grades by histological changes in the intima and media.After second week, the plantar ulcer was revealed, and increased in number afterfourth week.The ulcer formation was related with the arterial changes as intimal thickening andluminal stenosis.The eripheral nerve fibers were reduced in distribution, especially on the media ofarterial wall and in the dermis of plantar region after two weeks of denervation and afterthree weeks nerve fibers were completely disappeared in the wall of artery and the periarterial region.The author have observed that the arteriolar lesion was induced by the resection ofsciatic nerve may result in the formation of plantar ulcer which is similar to the ulcerof leprosy. So we concluded that the incurable plantar ulcer in leprosy might be promoted bythe vascular damage induced by peripheral nerve change.

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CBA/JN系雄マウスの左足蹠皮下にMycobacterium leprae Kurume-Naha株の104を接種し,その2週後よりM. leprae[M. leprae感染アルマジロ肝(γ照射)よりIMMLEPの2相分配法により精製]及び凍結乾燥BCG(日本BCG研究所)より調製した混合ワクチン[1×109/ml M. leprae (1容)+4mg/ml BCG (1容)]の50μl宛をマウスの背部皮下に2週に1回の割で26週に亘って投与した。ワクチン効果の判定は感染マウスの足蹠当りのM. leprae菌数をShepardの方法に準じて計測することによってなされた。その結果,感染118日目では,ワクチン投与群の足蹠内菌数は対群に比べて若干多かったのに対して,感染187日目で逆にワクチン投与群において対照群におけるよりもや少ない傾向がみられたが,何れの場合を問わずワクチ投与群と対照群との間には有意差は見出せなかった。って,今回の実験の限りでは,BCG生菌とM. lepr死菌よりなる混合ワクチンはマウスの実験ライに対し治療効果を示さないものと結論づけられよう。

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