Nine biopsy specimens from 3 tuberculoid (TT), 1 borderline tuberculoid (BT), 2 borderline (BB), 2 borderline lepromatous (BL), and 1 lepromatous (LL) patients were studied using immunoperoxidase procedures with monoclonal antibodies. In TT patients 4B4
+, TCR α β
+, CD 4
+ T cells were dominant in dermal granulomas. In LL patient, dermal granulomas with 4B4
+, TCR α β
+, CD 4
+ T cells and 2H4
+, TCR α β
+, CD 4
+ T cells also had CD 8
+ T cells. The proportion of 4B4
+ T cells increased in granulomas from LL to TT and 2H4
+ T cells proportionately increased from TT to LL. TCR γ δ
+ T cells were detected only in BB and BL patients. However, there is no difference of staining pattern of ICAM-1 or LFA-1 antigen in any type of leprosy.
These results indicate that the immunohistochemical pattern of T cells (CD 4, CD 8, 4B4, 2H4, TCR) may be useful in the diagnosis of the spectrum ofleprosy.
抄録全体を表示