Hirosaki Medical Journal
Online ISSN : 2434-4656
Print ISSN : 0439-1721
Volume 63 , Issue 1
Showing 1-7 articles out of 7 articles from the selected issue
Original Article
  • Keiko Kayama
    2012 Volume 63 Issue 1 Pages 1-11
    Published: 2012
    Released: July 20, 2021
    JOURNAL FREE ACCESS
    Purpose: This study aimed to determine the current circumstances and challenges facing the Certified Procurement Transplant Coordinator (CPTC) system in Japan and to identify areas for improvement.
    Materials and Methods: A questionnaire survey was conducted of 35 practicing CPTCs, 7 former CPTCs, and Organ Transplant Service Officers (OTSOs) in 20 prefectures of Japan.
    Results: Practicing CPTCs responded that they felt "anxious about the CPTC employment system", perceived a "lack of experience based on regional disparities in numbers of organ donors", and wanted to see "improvements in the CPTC training program". These responses were similar to the reasons for resignation provided by former CPTCs. OTSOs responded that they "do not approve" of their current Organ Transplant Support Project (OTSP) and that there were no evaluation criteria in place to help convince the government to provide project funding.
    Conclusion: A CPTC training program that guarantees the status of CPTCs in Japan and reflects current regional circumstances such as numbers of organ donors needs to be established.
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  • Kunihiko Nakamura, Megumi Mikuniya, Shingo Takanashi, Akihito Hayashi, ...
    2012 Volume 63 Issue 1 Pages 12-20
    Published: 2012
    Released: July 20, 2021
    JOURNAL FREE ACCESS
    Introduction: Although analysis of bronchoalveolar lavage fluid (BALF) is a useful examination to assess airway inflammation, it is an invasive technique with limitation and risk of complications.
    Objectives: The aim of this study was to examine molecules in exhaled breath condensate (EBC) in comparison with BALF, and to clarify the clinical usability of EBC.
    Methods: EBC was collected from sixteen subjects suspected to have sarcoidosis just before BAL. The 40 different inflammatory molecules in EBC and BALF were analyzed by protein array.
    Results: BALF levels of 6 molecules including soluble tumor necrosis factor receptor type II (sTNF-RII) and regulated upon activation, normal T cell expressed and secreted (RANTES), and EBC levels of 13 molecules including sTNF-RII and RANTES were significantly correlated with percentage of lymphocyte in BALF (%Lym). We found significant correlations between levels of EBC and BALF in 16 out of 40 molecules. Levels of macrophage colony-stimulating factor (M-CSF), RANTES, TNF-α and sTNF-RII in EBC were significantly correlated with BALF. Their levels in EBC and BALF also were correlated with %Lym.
    Conclusion: Protein array, a highly sensitive approach allowed us to detect inflammatory molecules in EBC. Comprehensive analysis of EBC might be an equivalent to that of BALF.
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  • Yohei Nishikawa, Yasushi Matsuzaki, Kazuyuki Kimura, Hideo Kitamura, H ...
    2012 Volume 63 Issue 1 Pages 21-27
    Published: 2012
    Released: July 20, 2021
    JOURNAL FREE ACCESS
        Retinoic acid-inducible gene-I (RIG-I) is a cytoplasmic receptor recognizes the double stranded RNA derived from viruses, and activates antiviral responses such as the production of type 1 interferon (IFN). IFN-β (type 1 IFN) has been established as one of the treatments for malignant melanoma. This study investigated the effects of various cytokines, including IFN-β, on RIG-I expression and cell growth in human melanoma cells. IFN-β upregulated RIG-I expression in a number of human melanoma cell lines except for MeWo melanoma cells. The cellular proliferative potential of 501mel cells, which represented the IFN-β-induced RIG-I upregulation, was suppressed by IFN-β. However, MeWo cells under conditions of IFN-β stimulation showed neither RIG-I upregulation nor suppression of cell growth. Therefore, we introduced the RIG-I expression vector to MeWo cells and examined the cell growth. The result showed suppression of cell growth by IFN-β, indicating that RIG-I plays essential roles for the inhibition of the cellular proliferative potential by IFN-β. Thus, we revealed the existence of melanoma cells lacking the expression of RIG-I protein, and suggested that expression levels of RIG-I in melanoma tissues may determine how effect IFN-β treatment has on melanoma of these patients.
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  • Shuhei Koeda, Ippei Takahashi, Takashi Umeda, Masashi Matsuzaka, Koshi ...
    2012 Volume 63 Issue 1 Pages 28-37
    Published: 2012
    Released: July 20, 2021
    JOURNAL FREE ACCESS
        The purpose of this longitudinal study was to reveal the effects of physique, body composition, and lifestyles on bone mineral density (BMD) in the early teens. Subjects of the current study were 73 boys and 73 girls. Osteo-sono assessment index (OSI), body mass index (BMI), body fat percentage and fat-free mass index (FFMI) were measures. All subjects were measured at two points; 5th grade and 8th grade. The association between changes in these values and the OSI at 8th grade were evaluated with multiple regression analysis. Positive correlations were observed between the OSI and exercise time/FFMI in both sexes. Furthermore, this trend was also observed between the OSI and BMI in boys. The results suggested that an increase in exercise time and FFMI are factors that may enhance BMD in both sexes. However, the increase in BMI was found to increase BMD only in boys. Such gender difference was suggested to be the result of what BMI represents for each group. For boys, increased BMI reflects the increasing amount of muscle mass, whereas for girls, it mainly reflects an increase in body fat. Therefore, muscle mass needs to be increased by long periods of exercise in order to increase BMD, especially in girls.
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  • Koshi Sumigawa, Ippei Takahashi, Masashi Matsuzaka, Kazuma Danjo, Shuh ...
    2012 Volume 63 Issue 1 Pages 38-47
    Published: 2012
    Released: July 20, 2021
    JOURNAL FREE ACCESS
    Purpose: To clarify how osteoporosis is influenced by the period after menopause.
    Methods: Our participants comprised 756 females. We used a questionnaire to ask participants about their lifestyle, number of deliveries, and age at which menopause occurred. We measured bone density, body mass index (BMI), body fat percentage (BFP), total body muscle index (TBMI), and lower limb muscle index (LLMI) during each of the following periods: before menopause, up to 15 years after menopause, and more than 16 years after menopause.
    Results: TBMI, BMI and BFP were significantly higher in premenopausal participants with higher bone density. Furthermore, higher bone density was observed in participants who had given birth fewer times had a and higher frequency of exercise. TBMI, LLMI, BMI and BFP were significantly higher in participants up to 15 years after menopause with higher bone density, and a trend wherein they were higher in participants who had progressed significantly fewer years after menopause was observed. TBMI, LLMI and BMI were significantly higher in participants more than 16 years after menopause with higher bone density.
    Conclusion: Risk factors for osteoporosis differed according to the number of years after menopause. Especially for postmenopausal women, it is important to maintain/increase lower limb muscle mass.
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  • Chikara Iino, Tadashi Shimoyama, Takao Oyama, Daisuke Chiba, Takashi U ...
    2012 Volume 63 Issue 1 Pages 48-54
    Published: 2012
    Released: July 20, 2021
    JOURNAL FREE ACCESS
        Severe atrophic gastritis in aged Helicobacter pylori-positive patients leads to the decrease of the level of amount of H. pylori in gastric mucosa. Cut-off value for E-plate (a serum H. pylori antibody kit) has been set regardless the age of the subjects. The aim of this study was to estimate appropriate cut-off values for E-plate in younger and elderly subjects. A total of 994 healthy adults who received a health survey in Iwaki area of Hirosaki City in 2005 were tested. We divided the subjects into two groups; the elderly group included 594 subjects who were born before 1950 and the younger group included 400 subjects who were born after 1950. We evaluated appropriate cut-off values of E-plate by stool antigen test as gold standard. The ROC curves showed the best cut-off level to be 12.5 U/ml (sensitivity: 94.2%, specificity: 84.0%) in elderly group and 14.5 U/ml (sensitivity: 93.4%, specificity: 89.4%) in younger group. False positive results of E-plate were more frequent in elderly group (P < 0.001). Cut-off values of E-plate should be decided according to the age of the subjects.
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  • Takanobu Iwama, Kazuma Danjo, Masashi Matsuzaka, Ippei Takahashi, Hiro ...
    2012 Volume 63 Issue 1 Pages 55-65
    Published: 2012
    Released: July 20, 2021
    JOURNAL FREE ACCESS
        The epidemiological research was carried out to investigate the relationship between brachial-ankle pulse wave velocity (baPWV) and atherosclerosis-related factors. Subjects were 1,730 Iwaki residents (Aomori Prefecture, Japan) who participated in the Iwaki Health Promotion Project between 2005 and 2010. They were divided into different genders and age group. The results were analyzed using multiple linear regression analysis with baPWV as a dependent variable, and atherosclerosis-related factors as independent variables. In male of the youngest age group, baPWV was found to have a significant positive correlation with the number of cigarette consumption per day. In female of the youngest age group, baPWV was found to have significant positive correlations with triglyceride and glucose levels, and a significant negative correlation with frequency of exercise. Therefore, cigarette smoking in young male was suggested to be a major risk factor, and exercise habit in young female was suggested to be a preventive factor of atherosclerosis.
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