Manda Koso is a commercial fermented plant product (FPP) made from 53 types of fruits and vegetables that are fermented for more than 3 years. We hypothesized that the FPP can prevent infection by influenza virus and human norovirus. Therefore, we investigated the effects of the FPP on influenza virus and feline calicivirus, a surrogate of human norovirus. We found that 10% FPP inactivated the influenza virus but not the feline calicivirus. Inhibition of the influenza virus was highly concentration-dependent: 1% and 0.3% FPP showed reduced inactivation efficacy. The effects of the FPP on the influenza virus-infected cells were investigated by addition of the FPP to the culture medium after virus infection. No suppressive effect of the FPP on influenza replication in MDCK cells was observed. The results showed that the FPP could inactivate influenza virus by affecting the virus particles.

Purpose: The principle treatment of infectious aortic aneurysm is to remove the infected aneurysm and replace it with Rifampicin-soaked prosthesis by omentopecxy. This study aimed to clarify the efficacy of long-term antibiotics and subsequent thoracic endovascular aneurysm repair (TEVAR) for infectious thoracic aortic aneurysm.

Methods: Between July 2011 and December 2015, 213 TEVARs were performed at Hiroshima University Hospital. Six patients (2.8%) had infectious aneurysm and received long-term antibiotic therapy and secondary TEVAR. Long-term antibiotic therapy and subsequent TEVAR is paradoxical. This study aimed to clarify the timing of TEVAR for infectious thoracic aortic aneurysm.

Results: All patients presented with fever and back pain, and had positive blood cultures; five patients had significant co-morbidities. Bacteraemia was caused by Methicillin Sensitive Staphylococcus Aureus (MSSA) (2), Streptococcus sanguinis (1), Methicillin Resistant Staphylococcus Aureus (MRSA) (1), Chryseobacterium meningosepticum (1), and Enterococcus faecalis (1). Blood examination at admission revealed a WBC count ranging from 10,470 to 16,170/μl and CRP ranging from 7.9 to 16.4 mg/dl. Long-term antibiotic therapy was continued until WBC and CRP were within the normal range. TEVAR was performed emergently in 3 cases and electively in 3 cases. The time from admission to TEVAR ranged from 7 to 26 days. One stent-graft was deployed in all 6 cases. All patients survived and were followed for an average of 48 months; they were free from re-infection.

Conclusion: Long-term antibiotics and simple TEVAR may be a feasible treatment for infectious thoracic aortic aneurysms.

Measurement of neck circumference (NC) is an easy method to assess obesity. Our investigation to estimate risks for metabolic disease in Japanese postmenopausal women indicated that NC is significantly associated with whole-body obesity indices and visceral fat accumulation. To clarify the early stage of metabolic changes and confirm NC validity as a predictor of metabolic syndrome, NC’s association to the four obesity indices, namely, weight, body mass index (BMI), body fat, and waist circumference (WC), was examined in a college student group of 60 females aged 18.7±0.3 years. NC was mainly correlated with weight, followed by BMI, WC, and body fat. It was also significantly associated with weight and BMI, but not with body fat. The participants were divided into two subgroups: “sports-experienced” and “not-sports-experienced,” who had moderate and strong correlation coefficients with NC and WC, respectively. WC value was possibly predicted by NC values using linear functions for the group and its subgroups. The correlation between NC and WC, NC’s association to weight, and substitution of NC to WC were confirmed by the same analyses in another student group composed with 18 females aged 19.7±0.6 years. Our study showed that the distribution of body fat in college students is difficult to assess based on NC alone. Nevertheless, NC measurement is an easy, inexpensive, and reproducible method to assess obesity and a possible predictor to identify the risk for future metabolic diseases in Japanese college students with the four obesity indices, weight, BMI, body fat, and WC.

This study aimed to examine workplace environment that affects the workplace satisfaction of novice public health nurses (PHNs). An anonymous, self-administered questionnaire was sent to 670 PHNs working at municipalities. The survey comprised basic attributes, a comfortable workplace scale (Japanese version), and workplace satisfaction. We classified the PHNs into two groups, “novice” and “others,” based on their years of experience. We compared the scores on the comfortable workplace scale between the two groups. Multiple regression analysis was performed with workplace satisfaction as the dependent variable and comfortable workplace scale as the independent variable. Three hundred and fifty (52.2%) PHNs returned the questionnaire. Novice PHNs highly appreciated “human relations” and “work discretion” in their workplaces. The scores of novice PHNs on “career development” were significantly higher than that of the others. Workplace satisfaction in novice PHNs was improved by “human relations,” “labor load,” and “connection with society.” “Career development” affected other PHNs’ workplace satisfaction, but it did not affect the novice PHNs.

The presence or absence of murderous intent is an important fact during criminal trials. To verify autopsy findings that were considered as evidence of murderous intent, we compared autopsy findings in homicide cases committed with and without murderous intent (n = 12 and n = 11, respectively). Although the number of wounds may only be limited to one or two, stab wounds on the trunk of the body from a sharp instrument can be a significant evidence of murderous intent. Bruise or petechial haemorrhage at the back or limbs caused by blunt instruments or without any weapons do not indicate the presence of murderous intent. Although results in this study should be carefully interpreted in other jurisdictions, statistical analysis comparing cases with and without murderous intents might be a valuable methodology to understand autopsy findings involving murderous intent in Japan.