電気学会論文誌Ｅ（センサ・マイクロマシン部門誌）
Online ISSN : 1347-5525
Print ISSN : 1341-8939
ISSN-L : 1341-8939
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131 巻, 12 号
選択された号の論文の12件中1～12を表示しています
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特集：最先端半導体技術応用バイオメディカルデバイス
特集解説
特集論文
  • 半導体デバイスによるin vitro バイオセンシングに関するレビュー
    坂田 利弥, 杉本 東代, 宮澤 雄弥, 松瀬 雄亮, 前川 侑毅
    2011 年 131 巻 12 号 p. 409-413
    発行日: 2011/12/01
    公開日: 2011/12/01
    DOIhttps://doi.org/10.1541/ieejsmas.131.409
    ジャーナル フリー
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    We are studying and developing biosensing techniques in order to analyze and monitor simply and easily biological phenomena such as DNA recognition events antigen-antibody interaction, and cell functions in vitro. Particularly, we focus on the direct detection of ions or ionized molecules with charges, because most of biological phenomena are closely related to ionic or ionized molecular behaviors such as sodium or potassium ions through ion channel at cell membrane which are based on cell-cell communication for example, and DNA molecules also have intrinsic molecular charges based on phosphate groups. Our research activities contain interesting information not only for researchers in biology and molecular biology, but also researchers in electronics and physics. We believe that novel tool and method based on material and device sciences should be studied and developed for discovery of unknown biological phenomenon in the interdisciplinary field.
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  • 細胞サイズの脂質二重膜マイクロチャンバーにおける電流シグナル計測と経時安定性向上
    渡辺 吉彦, 大崎 寿久, 竹内 昌治
    2011 年 131 巻 12 号 p. 414-418
    発行日: 2011/12/01
    公開日: 2011/12/01
    DOIhttps://doi.org/10.1541/ieejsmas.131.414
    ジャーナル フリー
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    In this paper, we developed a microfluidic device for formation of artificial cell membranes (lipid bilayer membranes) and for electrical recordings of transmembrane currents. We succeeded in observing electrical current together with formation of transmembrane α-hemolysin nanopores at the bilayer membrane. In addition, we applied glass for the device material to target long-term stability of the formed bilayer membranes. With further development, we believe that the device will contribute to lower the cost and enhance the data throughput of the functional analyses of membrane proteins related to the drug discovery.
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  • 接触法による膜たんぱく質のアレイ化
    辻 祐太郎, 川野 竜司, 大崎 寿久, 佐々木 啓孝, 三木 則尚, 竹内 昌治
    2011 年 131 巻 12 号 p. 419-424
    発行日: 2011/12/01
    公開日: 2011/12/01
    DOIhttps://doi.org/10.1541/ieejsmas.131.419
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    This paper describes multiple ion-channel recordings through membrane proteins reconstituted in bilayer lipid membranes (BLMs) array. The BLMs array can be prepared by “Droplets Contacting Method” which forms BLMs at the interface of two lipid monolayers. Since this method does not require skilled techniques, it is highly reproducible and can be applied to automated system. We used a double well chip (DWC) for the droplets contacting method. We attempted to confine the BLMs forming areas with parylene micro-pore (parylene double well chip, PDWC) to augment the mechanical stability of BLMs. Subsequently, we arrayed the PDWC with electrodes for multiple recordings of channel proteins. We successfully demonstrated 14 channels simultaneous ion channel recordings through α-hemolysin.
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