Background: Dexmedetomidine has been indicated for sedation during non-intubation surgery and procedures performed under local anesthesia in Japan since 2013. We reviewed 10 patients who received dexmedetomidine during local anesthesia surgery at our hospital.
Methods: Dexmedetomidine was administered to patients scheduled for surgery under local anesthesia, who requested sedation, or were expected to undergo surgery for more than 1 h. The initial loading dose was 6 μg/kg/h, administered intravenously for 10 min, followed by maintenance dosing at 0.1–0.4 μg/kg/h. Vital signs and sedation levels were monitored during the surgery. Dexmedetomidine administration was terminated 15–30 minutes before the expected end of surgery. The sedation levels and side effects in each case were reviewed.
Results: Between 2018 and 2020, 10 patients underwent surgery in our hospital under local anesthesia and sedation with dexmedetomidine for diseases including abscesses, artificial infections, and benign and malignant tumors. Appropriate sedation levels were achieved in all cases. Adverse effects included respiratory depression and hypotension in two cases each. However, these were easily resolved by slowing down or stopping the drug administration or applying stimulation. No other adverse events were observed.
Conclusions: Dexmedetomidine is suitable for plastic surgery because patients can be easily awakened and can communicate even when appropriately sedated. Further, it causes lesser respiratory depression than other sedatives. In our case, respiratory depression and hypotension were observed; however, the patient recovered quickly, and the surgery could be performed relatively safely.
Procedure for sedation with dexmedetomidine (modified from reference
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