The effect of ^<60>Co-γ irradiation on the antibacterial activity of chlorhexidine hydrochloride was examined and the following results were obtained.1. The radioresistance of B. pumilus ATCC 27142 spore suspended in the solution of chlorhexidine hydrochloride was apparently higher than that in distilled water.2. The antibacterial activity of chlorhexidine hydrochloride irradiated in wet state decreased with an increase of irradiation dose, but that in dry state did not decrease. Upon irradiating chlorhexidine hydrochloride adsorbed on cellulose product, the antibacterial activity showed the similar tendency.

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