Japanese Journal of Medicine

The Pathological Physiology of Small Intestine

Masasuke Masuda

1974 Volume 13 Issue 3 Pages 165-171
Published: 1974
Released on J-STAGE: March 27, 2006

DOIhttps://doi.org/10.2169/internalmedicine1962.13.165

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It seems that the investigations, both basic and clinical, are underdeveloped in the field of small intestine, while the investigations in the field of stomach and liver have markedly developed. The author reported "mucosal metabolism and the clinical significance of digestive tract" as a special lecture at the 41st annual meeting of Japanese Society of Gastroenterology in 1955, and emphasized that the important role of small intestine is like that of liver. Since then, 18 years have passed. At the moment, I would like to speak about "the pathological physiology of the small intestine" at the 70th annual meeting of Japanese Society of Internal Medicine.

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(1) Relationship of Renin-Angiotensin-Aldosterone System to Cardio-renal Hemodynamics on Chronic Congestive Heart Failure

Reizo Kusukawa, Masahiko Kinoshita

1974 Volume 13 Issue 3 Pages 172-175
Published: 1974
Released on J-STAGE: March 27, 2006

DOIhttps://doi.org/10.2169/internalmedicine1962.13.172

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It has been reported that the renin-angiotensin-aldosterone (R-A-A) system is related to sodium retention in patients with heart failure. In 1946 "renin like material" was demonstrated to be present in renal venous blood.¹⁾ On the other hand, evidence that intrarenal distribution plays an important role in sodium regulation in man has led to increase in the interest in the use of Xenon-133 for assessing this function.²⁾ We attempted to measure the intrarenal distribution of blood flow in patients with chronic congestive heart failure and to correlate the renal hemodynamics to the R-A-A system.

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(2) A Clinical Study of the "Water-Electrolyte Regulation Mechanism" in Chronic Congestive Heart Failure with Emphasis on Renin and Catecholamine

Hiroshi Saimyoji, Yoichi Seriu, Masao Takayasu

1974 Volume 13 Issue 3 Pages 176-179
Published: 1974
Released on J-STAGE: March 27, 2006

DOIhttps://doi.org/10.2169/internalmedicine1962.13.176

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(3) Plasma ADH Levels in Congestive Heart Failure

Yoko Yamane, Toshiya Shiota

1974 Volume 13 Issue 3 Pages 180-184
Published: 1974
Released on J-STAGE: March 27, 2006

DOIhttps://doi.org/10.2169/internalmedicine1962.13.180

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The role of ADH in the failure of excretion of water and consequent edema formation accompanying congestive heart failure has been the subject of considerable recent investigations. As reported previously¹⁾, plasma ADH increased in 45% of cases with right-sided heart failure and there was a statistically significant correlation between ADH levels and right ventricular enddiastolic pressure or right atrial pressure. The present study was undertaken to elucidate the effect of elevated venous pressure on plasma ADH level and the role of ADH in retention of water in congestive heart failure.

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(4) Veins and Microcirculation in Relation to a Possible Mechanism for Body Fluids Control in Congestive Heart Failure

Senri Hirakawa

1974 Volume 13 Issue 3 Pages 185-187
Published: 1974
Released on J-STAGE: March 27, 2006

DOIhttps://doi.org/10.2169/internalmedicine1962.13.185

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A suggestive evidence that a hitherto unknown mechanism favoring the reabsorption of body fluids from tissue space into blood is operative in man has been presented by Hayase¹⁾ who found that certain osmotically active substances made their appearance in the antecubital venous blood of many cardiac patients with elevated ante-cubital venous pressure. A number of animal experiments with acute systemic venous congestion were then carried out in this laboratory^2-4) to explore the factual aspect of a similar phenomenon in dogs. Thus investigation centered around the phenomenon of the shift of osmolal arterio-venous difference, arterial minus venous, to be abbreviated hereafter as Osm A-V, towards more negative levels during venous congestion.
Some of the more recent findings obtained in this laboratory, by a joint effort of professor Hayase and his colleagues, are described below.

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(5) Role of the Kidney in Sodium Retention in Cardiac Failure

Eiichi Kato, Takao Wada

1974 Volume 13 Issue 3 Pages 188-191
Published: 1974
Released on J-STAGE: March 27, 2006

DOIhttps://doi.org/10.2169/internalmedicine1962.13.188

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(6) A Simulation Study of Na Metabolism Three Types of Body Fluid Volume Regulation

Masahito Nagasaka

1974 Volume 13 Issue 3 Pages 192-194
Published: 1974
Released on J-STAGE: March 27, 2006

DOIhttps://doi.org/10.2169/internalmedicine1962.13.192

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(7) Pathogenesis of Occurrence of Hypoproteinemia in Patients with Congestive Heart Failure and Its Significance

Yasushi Yokota, Takanobu Mizuguchi, Hironori Toshima, Noboru Kimura

1974 Volume 13 Issue 3 Pages 195-197
Published: 1974
Released on J-STAGE: March 27, 2006

DOIhttps://doi.org/10.2169/internalmedicine1962.13.195

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