Japanese Journal of Medicine
Online ISSN : 1881-123X
Print ISSN : 0021-5120
18 巻, 3 号
選択された号の論文の7件中1~7を表示しています
  • I. Lipid Peroxide and Lysosomal Enzymes in Rheumatoid Joints
    Toshikazu YOSHIKAWA, Nobuyoshi YOKOE, Shuhei TAKEMURA, Haruki KATO, Ke ...
    1979 年 18 巻 3 号 p. 199-204
    発行日: 1979年
    公開日: 2006/03/27
    ジャーナル フリー
    Sera and synovial fluids from patients with rheumatoid arthritis (RA), and with osteoarthritis (OA) as a control, were investigated for lipid peroxide level, β-glucuronidase activity, acid phosphatase activity, and α-tocopherol level. Lipid peroxide level β-glucuronidase activity and acid phosphatase activity were found to increase in synovial fluids of RA patients, suggesting that the generation of lipid peroxide in the rheumatoid joints plays a role in the liberation of lysosomal enzymes into the synovial fluids. Signiflcant correlation was demonstrated between lipid peroxide and β-glucuronidase, and or acid phosphatase in synovial fluids from RA patients. Increased α-tocopherol level in RA synovial fluids might be explained by the increased vascular permiability in the rheumatoid joints since there was no difference in α-tocopherol level between RA and OA sera. The data led us to conclude that the increase of lipid peroxide in the synovial fluids in the rheumatoid joints played an important role in lysosomal instability of either synovial lining cells or influxed polymorphonuclear leukocytes.
  • SG TEWARI, I HUSAIN, MH KHAN, M PRASAD, Ch RU KHAN, SHAKUNTALA
    1979 年 18 巻 3 号 p. 205-209
    発行日: 1979年
    公開日: 2006/03/27
    ジャーナル フリー
    Twenty-one laparotomy and histologically proved and 11 clinically diagnosed but identical patients of abdominal tuberculosis were studied for various clinical and biochemical evidences of adrenal involvement. In both the groups, direct as well as indirect tests of adrenal cortical functions were found to be deranged. Both basal and post ACTH infusion plasma cortisol and urinary 17-ketosteroids were found to be significantly lower in patients as compared to controls. It is concluded that most of the patients with manifest abdominal tuberculosis suffer from latent clinica land/or biochemical adrenal cortical insufficiency and have a gross inability to respond to stress situations. Awareness of this condition and prompt therapy by corticosteroids at times of stress in these patients may be well justified and needs further evaluation by controlled trials.
  • A Long-Term Follow-up Study
    Yasushi NAKAMOTO, Kazuhiro DOHI, Masahiko FUJIOKA, Hiroshi KIDA, Nobu ...
    1979 年 18 巻 3 号 p. 210-217
    発行日: 1979年
    公開日: 2006/03/27
    ジャーナル フリー
    Twenty-four cases with primary and secondary RPGN were divided into three groups according to the type of treatment ; group 1 received anticoagulants, steroids and cytotoxic drugs (8 cases), group 2 received steroids and immunosuppressives alone (10) and group 3 had neither form of treatment (6). Doses of immunosuppressives were same in group 1 and 2. All cases in group 3 died of uremia within the first 2 years. Six of 8 cases in group 1 (75%) and 4 of 10 in group 2 (40%) survived beyond 2 years, with variable recovery of function. Although statistically not significant, the combined regimen appeared to accelerate histological improvement. Cases with already advanced glomerular changes failed to respond. Gradual decline of a previously improved GFR was occasionally observed after withdrawal of treatment. Nevertheless, the survivors have not required hemodialysis for 4 to 8 years.
  • CT and Autopsy Findings
    Masakuni MUKOYAMA, Itsuro SOBUE, Toshiyuki KUMAGAI, Tamiko NEGORO, Kat ...
    1979 年 18 巻 3 号 p. 218-222
    発行日: 1979年
    公開日: 2006/03/27
    ジャーナル フリー
    The findings of computed tomography on Fukuyama type congenital muscular dystrophy were presented. They included low density area in the cerebral white matter with cortical atrophy. The pathologic examination of autopsied brain, on the other hand, revealed agyria and micropolygyria of the cerebral and/or cerebellar cortices, and maldevelopment and poor formation of the myelin in the cerebral white matter and pyramidal tracts in the brain stem. These pathologic alterations were considered to indicate a dysgenetic or dysplastic process, occurring in early uterine life. Intimate correlation between CT findings and neuropathologic observations of the brain was mentioned. Repeated CT examination would be convenient for taking care of these patients.
  • Motonobu SUGIMOTO, Yasukiyo SUMINO, Tohru ABEI
    1979 年 18 巻 3 号 p. 223-227
    発行日: 1979年
    公開日: 2006/03/27
    ジャーナル フリー
    A 27-year-old male was admitted to the Toho University Hospital with icterus and massive right pleural effusion containing 4.Og/dl of protein. The hepatocellular dysfunction and positive HBs antigen were revealed and he was diagnosed as typical acute viral hepatitis, type B. Evaluation for his pleural effusion presented no evidence of pulmonary parenchymal disease, tuberculosis, or other systemic disorder. Since the effusion resolved with normalization of liver function tests, it is most likely that the effusion was a complication of viral hepatitis. Cases with pleural effusion as the presenting sign of viral hepatitis are rare in the recent medical literature. A survey of publications disclosed the presence of this association in at least 11 patients, not including our own.
  • Toshitsugu ODA
    1979 年 18 巻 3 号 p. 228-234
    発行日: 1979年
    公開日: 2006/03/27
    ジャーナル フリー
  • Satoru MURAO, Chuichi KAWAI, Michitoshi INOUE, Keiji UEDA, Kanji OBAYA ...
    1979 年 18 巻 3 号 p. 235-249
    発行日: 1979年
    公開日: 2006/03/27
    ジャーナル フリー
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