Changes of serum protein, especially of globulin fraction, in patients with nephrotic syndrome observed by various methods of protein analysis were studied in this report.
The analysis of changes in serum protein in malignancy is in itself a means of studying abnormality in the protein metabolism in this condition. The present study was conducted in order to elucidate the mechanism of hypoproteinemia in cancer by analyzing the clinical statistics, by studying the changes of albumin metabolism, and the role of the liver in the evolution of hypoproteinemia. Studies were also directed to the changes of globulin fractions from the patho-physiological standpoint, and changes of serum globulin fractions associated with the phenomenon of hypoproteinemia in cancer were analyzed.