By means of paperchromatography, the author conducted qualitative measurements of free amino-acid in tuberculous pulmonary cavities and encapsulated caseous foci. The results were as follows:
1. From the contents of cavities and encapsulated caseous foci, cystine, asparatic acid, glycine, alanine, arginine, proline, valine and leucine were detected.
2. In the average, the cavities contained per focus 5 kinds of free amino-acid and per encapsulated caseous foci 3 kinds of the same.
3. In case of cavities, cystine showed the highest rate of detection and followed by asparatic acid, alanine, proline, glycine, leucine, valine and arginine in rank. In case of encapsulated caseous foci, the rank was graded as follows: Cystine, asparatic acid, proline, alanine, glycine, arginine, valine and leucine.
4. In case of cavities, there were no considerable differences in the number of free aminoacid by size of the cavities. While in case of encapsulated caseous foci, number of the kinds of free amino-acid increased in proportion to the size of the lesion.
5. As for relation between free amino-acid and bacilli, in multibacilli such as type D and type Z, many kind of free amino-acid were revealed and few in the few bacilli group such as type W. In encapsulated caseous foci, positive bacilli group had more number of free amino-acid than negative bacilli group.
6. In softening encapsulated caseous foci, number of free amino-acid was more than in nonsoftening ones.
7. Between free amino-acid found from cavities and the dose of antituberculous drugs, no remarkable relation was revealed. It was recognized that newer foci had more free aminoacid than older ones.
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