Sulfhemoglobinemia caused in rabbits with the administration of both sulfur and phenacetin was studied pathologically and also their ventilatory functions were observed with the following results.
1) Pathological findings:
(1) There were scattered many multiple and superficial acute ulcers in the stomach, accompanying with the chornic or subacute gastritis.
(2) In the brain, there were noted the edema with the slight infiltration of inflammatory cells in the subarachnoid.
2) The ventilatory function tests which were performed with the instruments devised for the rabbits in our laboratory revealed as follows:
(1) At rest, the values of VF, V02 and Vco2 all decreased comparing with those of the normal rabbits.
On the contrary, all of the values indicating the ventilatory capacity such as V
E, f, V
E, VO
2 and VCO
2 increased at exercise except R. Q. which showed remarkable low value.
(2) In the studies of blood gas exchange, Sao and PaO
2 revealed very decreased values.
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