For discerning the abnormal coagulability related to abnormal bleeding or thrombosis, 1) tourniquet test (Rumpel-Leede phenomenon), 2) thrombotest (Owren), 3) one-stage prothrombin time (Quick) and 4) measurement of the plasma fibrinogen level were performed. 29 cases of liver disease, 19 cases of diabetes mellitus, 12 cases of chronic nephritis and 13 cases of biliary tract disease were subjected to the above examinations.
Then the above tests were performed before and after administration of ε-aminocaproic acid which is an anti-fibrinolytic agent. The results obtained are as follows:
1) Although tourniquet tests were positive in most cases of each group, liver disease and diabetes mellitus were moderately to highly positive.
2) Blood coagulation tested by thrombotest and prothrombin time diminished in most cases of liver disease, and few cases of which diminished markedly.
Although some cases of chronic nephritis and biliary tract disease slightly decreased in coagulability, in most cases, especially of diabetes mellitus were normal or perhaps increased.
3) Plasma fibrinogen level decreased in some cases of liver diseae, wherease in others increased. In the other groups of disease, however, it showed almost exclusively increased tendcrcy.
4) As to the effect of ε-amino-caproic acid on liver disease and the others,
i) negativation of positive tourniquet test, ii) increased value of thrombotest, iii) decreased prothrombin time associated with decreased Plasma fibrinogen level were observed.
Conclusion:
1) Hypocoagulability associated with the damage of small vessels as seen in liver disease may induce abnormal bleeding, whereas hypercoagulability as seen in diabetes mellitus would produce thrombosis.
2) As shown by the effect of ε-amino-caproic acid, hypocoagulability in liver disease would be based on accentuation of fibrinolysis (proteolysis).
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