1) Therer are remarkable individual differences among active INH serum concentrations, in which the mean value is slightly higher in male than in female, and lower in Japanese than in Europeans. The metabolic pattern does not change in rabbit regardless of its affection of tuberculosis.
2) The value of active INH in serum increases on administration of PAS, sulfas or glucosamin at the same time. On some cases, there is no influence of these drugs.
3) The value of active INH in serum increases and is maintained much longer in the case of liver dysfunction both in human and rabbit. This may be due to the compensatory increase of free hydrazone type of INH, that is caused by decreased acetylation in the affected liver.
4) The value of active INH within organs of rabbit reveales a marked individual difference and the highest value is obtained in the kidney and next in the lung, liver, blood, brain and in the spleen in the decreasing order and decreases as the time passes by, just parallel with that in the serum. When the INH dosage is above 12mg/kg, the order changes as follows; the kidney, brain, blood, lung, spleen and liver. The same tendency is observed in liver when INH is administered together with PAS, sulfas or glucosamin.
5) S type is observed in the patient who is strongly resistent to INH, while R type is observed in the patient who is moderately resistent to INH and in the patients who experienced burst during the course of INH therapy.
6) The value of active INH in the caseous substance of lung lesions is highly related to the softend conditions of caseous substance, and that is not related to the capillary proliferation of wall.
7) Anti-INH substance is detected in tubercular Gaseous substance, culture filtrate, decomposing products of tubercle bacilli and serum of patient. The amount of that is seen more in INH resistent bacilli than in sensitive bacilli, and more in the patients than in healthy persons.
抄録全体を表示