Clinical and laboratory studies were established on 7 cases with hemophilia A and 2 cases with hemophilia B.
1) The age of the patients in the first visit to our clinic were less than 5 years old, except for one case. The age of their initial hemorrhagic manifestaticns appeared between 2 weeks and 11 months. Hemarthrosis, ecchymosis, oral bleeding and excessive bleeding after trauma were common manifestations in both types of hemophilia.
2) Family history were examined in three generations. Four patients of hemophilia A and one patient of hemophilia B showed sex linked recessive transmission and another cases occured sporadically.
3) The tests for the diagnosis of hemophilia were carried out as follows: a) Routine test. Clotting time, bleeding time, platelet cell count, prothrombin time and partial thromboplastin time, b) Identification tests, thromboplastin generation test and assay of factor VIII or factor IX.
Bleeding time, platelet cell count and prothrombin time in all cases of hemophilia A and B were within normal range and partial thromboplastin time was markedly prolonged. Clotting time of 5 cases with hemophilia A revealed over 60 minutes and factor VIII level showed 0 per cent. Two cases of clinically mild type showed moderate prolongation of clotting time (20 to 25 minutes) and 4-6 per cent of factor VIII. Two cases with hemo-philia B were clinically severe and their factor I revealed lower than 2 per cent.

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Prevalence of chronic bronchitis in 13, 846 inhabitants above forty years old in Sakai was surveyed.
This survey was based on questionnaire on each person and 2, 265 persons of them having any respiratory symptomes submitted clinical examinations by the doctors.
The chronic bronchitis was defined as production of sputum and having persistent or recurrent cough for three months or more in at least two consecutive years.
The prevalence increased with age and amount of smoking cigarettes, and these factors was statistically standardized.
The prevalence of chronic bronchitis was 2.0%-5.6% in men and 0.7%-2.5% in women checked-up.
The prevalence was significantly greater in the more polluted area (Sanbo, Eisho, Yuya) than in the less polluted area (Kamiishi, Kanaoka, Hamadera, Nishitoki) indicating that air-pollution (especially SO₂ concentration) had significant effect on the incidence of chronic bronchitis.

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The authors studied the in-vitro incorporation of 1-C_-14-acetate into major fatty acids by diabetic whole blood and platelets suspended in own plasma. Although the C_-14 incorpo-ration into fatty acids is generally suppressed in diabetes, relatively great suppression of C_-14 incorporation is observed at palmitate and myristate made via malonyl Co-A pathway and relatively less suppression is seen at stearate and 20-carbon fatty acids made via chain-lengthening pathway. The grade of abnormalities of the C_-14 incorporation seems to be closely related to the severity of diabetes.
With 1.47 ×10^-2 Mol/l alloxan, the typical diabetic pattern of C_-14 incorporation is repro-duced both in whole blood and platelet suspension derived from healthy subjects. At a given concentration of alloxan, the diabetic pattern appears more strongly in platelet suspension than in whole blood. In platelet suspension, alloxan can definitely reproduce the diabetic pattern even at the concentraton of 0.2 ×10^-2 Mol/l (28.5mg%).
Both dehydroascorbic and ascorbic acids also reproduce the typical diabetic pattern of C_-14 incorporation in healthy whole blood and in platelet suspension. Between these two compounds dehydroascorbic acid exhibits stronger effect in either whole blood or in platelet suspension. And between the two incubation media, platelet suspension show more extensive pattern of diabetic C_-14 incorporation at a given concentration of either one of dehydroascorbic and ascorbic acids. In platelet suspension of healthy subjects the diabetic pattern is clearly reproduced with ascorbic acid at the concentration of 5.68 ×10^-6 Mol/l (Img%).
As C¹⁴O₂ production from the incubated whole blood with one of alloxan, dehydroascorbic and ascorbic acids is definitely increased as compared with that from control samples, the above three compounds seem to accelerate the function of citric acid cycle.
Some uncouplers of oxidative phosphorylation such as barbital, progesterone, cortisone, 1, 2-naphthoquinone and vitamin K₃ also reproduce the typical diabetic pattern of C_-14 incor-poration.
From the results described above it could be suggested that alloxan, dehydroascorbic and ascorbic acids act as uncouplers of oxidative phosphorylation and bring about suppressed production of ATP which in turn reproduce the diabetic pattern of C_-14 incorporation, and that the “-CO”radical of the above three compounds functions as an important key factor for the appearance of the diabetic pattern of C_-14 incorporation in both healthy whole blood and platelet suspension.

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During 1960-Oct. …1963-Feb., we found 35 cases of VUR in 400 retrograde or voiding cystourethrogramms, which were performed for infants or children with pyelonephritis, imperforated anus, abdominal tumours, various urological diseases or with disorders in other systems. 14 boys, 21 girl, and 9 cases of right side, 10 of left, and 16 of bilateral reflux,
We recognized that the incidence of reflux decreases according as children become elderer;28.2% in 0 to 1 year old, 13.5% in 1 to 3 years old, 5.6% in 3 to 6, 3.5% in 6 to 15.
Pyuria or bacteriuria were revealed at the first time of the cystogramms in 13 cases, who had never signs of urinary tract infection, while other 7 cases had nothing of any pathological elements in their urine.
Having been analysed 13 cases, which were examined repeatedly over 3 times in a year, they could be classified to three groups.
Group-I;VUR was demonstrated on the cystogramm only once at the first examination, and afterwards, no more reflux and no pyuria: 7 cases,
Group-II;VUR was demonstrated at every times of examinations and the reflux was progressively worse: 4 cases.
Group-III;VUR was sometimes intensive, but sometimes disappeared: 2 cases,
We concluded that,
(1) demonstrable uropathy is not always found in case of VUR, ;
(2) the more young the child is, the more often VUR is discovered.;
(3) we experienced often such a case, which has no pyuria or no bacteriuria, but vivid VUR exists, and which has clearly urinary tract infection, but no VUR.;
(4) we have to consider more seriously the indication for the VUR. It needs to observe repeatedly those cases to find the operation chance, for one year, at least, or more over, if possible.;and
(5) voiding cystourethrogramm is absolutely necessary to find the VUR;there are many cases, which VUR are found only by the voiding cystogram, in spite of nothing by the retrograde cystogramm.

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Dermatomycosis in which the pathogenic microorganisms could be recognized in this hospital were summed up to 561 during two years from January 1, 1967 to December 31, 1968: these cases occupied about 11.5% of the total number of the new patients and about 8.4% of the total skin-diseases during the same period. Trichophytia was 82.0% of the total dermatomycosis and it was all superficial trichophytia except each one case of Kerion Celsi and sycosis trichophyticus s, parasitaria. The dermatophytes were cultivated as to all the cases of trichophytia and 230 strains were obtained during 198: there were contained 170 strains of Tricltophyton rubrum (73.9%), 56 of Triclzq hytcn nuntagrcphytcs (24.3%), 3 of Epidermophyton floccosum, and 1 of Microsporum gyfreum. The successful separation ratio was about 83.6%. Pityriasis versicolor was about 5.3% of the total-dermatomycosis, which contained a case of a 4- month-old girl whose forehead was attached with the disease. Cutaneous candidiasis was about 11.9% of the total dermatomycosis and was all caused by Candida albicans. Interdigital erosion was most observed next to paronychia and onychia. An obvious relation was seen between these types of candidiasis and washing or scullery work, considering the particular circumstances in this district. Candidiasis was found in the parts under goldring, sticking-plaster and adult-diaper as uncommon cases;these cases were much or less “interitrigo”: only one case on the nose having no relation with “intertrigo” was seemed to be a medically caused disease due to corticosteroid ointment. Among the cases of Trichophytia, there were observed con-siderably many cases seem to be medically caused. Though erythrasma were observed in three patients, its precise reports are shown in a table only here as it is now thought to be a bacterial disease. As Atami district is a warmer part in Japan and one of the most famous spa and resort, there are seen particular structures of population and occupation in this district. Considering such circumstances, dermatomycosis was studied clinically and mycologically, but extreme difference was not observed comparing the findings at Atami with the reports about other districts in Japan, except the relations between occu-pation and some of candidiasis.

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Three cases of gastric lesion were examined and reported, in whom radiological, surgical and pathological findings were different one another before and after operation.
Case 1. 40-years-old man. The lesion was thought to be cicatrized ulcer at lesser curvature of antrum before operation, but exstirpated stomach showed small cancer invading into deep every layers and even subserosal tissue. Histologically it was composed of signet-ring cell carcinoma. Before operation it was suspicious for the existence of II-c type of early cancer in only one radiogram amomg fifteen pictures.
Case 2. 51-years-old man. A shadow-defect recognized at major curvature of gastric corpus, which was radiologically suspicious for a Borrmann's IV-type of cancer, revealed macroscopically and histologically an islet-like assemblance of giant mucosal rugae and non-cancerous lesions. The diagnosis was chronic gastritis hyperplastica circumscripta.
Case 3. 47-years-old female. It was cleared that the findings was the result of oppression to the stomach due to pancreatic hypertrophy and it's displacement, while radiological findings showed an infiltrative shadow defect at the posterior wall of gastric corpus and suspected for submucosal neoplasm before surgical operation.

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In rheumatid arthritis most patients desire eagerly to conquer their joint disabilities and walk themselves.
We reviewed here our orthopedic procedures given to 28 such patients in order to restore their ambulation.
After treatments of 22 patients, including 2 wearing crutches, got on their legs themselves, but the other 6 failed to do so.
Analyzing the results, it was concluded that in orthopedic procedures to R.A, joints conservative treatments or, as for operations, tenotomy of hamstrings or arthrodesis were moreuseful, while arthroplastic procedures to the weight bearing joints were less effective.

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Three autopsy cases of rheumatic arthritis, who died of generalized infection which must be responsible to steroid hormone therapy, were described.
Case 1. Female. Rheumatic arthritis occurred at the age of 27 years. She died of tuberculosis three years later from the onset.
Case 2. Male. Onset age of rheumatic arthritis was 50-year-old. Eight years after the onset of illness, he died of sepsis and paralytic ileus.
Case 3. Female. Onset age of the disease was 8-years-old. At the age of 13, she died. The cause of death was sepsis and polyarteritis nodosa.
We should pay special attentlon for prevention of infection during steroid administration against rheumatic arthritis.

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A 28-years-old woman with a large solid tumor occupying majority part of the right half of maxilla received partial resection of the maxilla. The histological feature showed central giant cell tumor. Clinical and histological differential diagnosis of neoplasm of this lesion and giant cell reparative granuloma was discussed.

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The patient was a boy aged 13 with perfect health record. One day, he was obscured consious suddenly, and was cramped a while ago. At admission, he was found to have hypertension that the initial count of blood pressure was 160-208/92-104 mmHg, and to have albuminuria and 27.2 mg/dl of urea-N. The right kidney was completely out of function according to excretory pyelography, retrograde pyelography and renogram, but any vascural disorder was not found by renal angiography and TRFR.
Due to malfunction of the right kidney, right nephrectomy was carried out, and its histological findings disclosed chrnoic pyelonephritis.
The blood pressure after operation had been kept at 130-150 mmHg and the condition of patient was excellent.

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