In the recent 3 years from July 1967 to September 1970, 160 cases of severe pulmonary tuberculosis were 6analyzed on the result of treatment and prognosis for finding out more adequate chemotherapy.
(1) The anti-tuberculous drugs were evaluated as follows; they were A class (INH, EB, TH, RFP, SM, KM, CPM), B class (PAS, CS, VM, PZA) and C class (SF, TBI). The rate of negative conversion of tubercle bacilli in sputum was higher in the combinations of three drugs in A class or two drugs in A and one in B (60%) than in the other combinations. Two drugs in A and one in C showed 40%. One drug in A and in C showed 25%.
(2) The improvement of X-ray findings was shown in 46% and the passing exacerbation was in 8% of 70 cases of the group of negative conversion of tubercle bacilli. In contrast, 52% in 90 cases of the positive bacilli group showed the exacerbation and only 11 ib showed the improvement in X-ray film. At the time of the exacerbation, drugs were used in weak combinations.
(3) 108 cases showed less than 50% of VC. PaO
2 and PaCO
2 were analyzed in 70 cases of them. Hypoxemia occured in 23 cases of the group of 50-41% of VC (29 cases) and in all of the group less than 40% of VC (41 cases). Hypercapnia was shown in 13 cases of the group less than 40% of VC.
(4) 39 cases died of causes as follows; pulmonary failure, hemoptysis, non-tuberculous disease and suicide. 46% of these cases involved pulmonary failure.
These findings suggest that the best result obtained when severe pulmonary tuberculosis is treated with the unused sensitive three drugs of A class. When bacilli are ont converted to negative after 3-4 months, all drugs should be changed to three or four other sensitive drugs at once. Furthermore, the lower respiratory function should be carefully controled.
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