Author has undertaken following experiment in order to investigate the effect of Streptomycin (SM) to leprosy. The subjects consist of 48 individuals: 45 lepromatous, 1 neural and 2 tuberculoid cases.
These subjects were deviled into two groups
(a) 20 cases of exclusive SM administration
(b) 2B cases of duplicate administration of SM with promin
The ways of administration were as follows: i. e. The day dose of SM was 1.0g intramusculary with maximum duration of 7 months ; the maxmum total dose was 150g and the minimum 40g and the results are summarized as follows
(1) The resorption of leproma and infiltration were 38% in group (a) and 85% iungroup (b).
(2) Improvement of nasal stoppages and ulcer were 57% in group (a) and 95% in group (b).
(3) Neuro-muscular symptoms (disturbance of both motility and sensory) showed almost no change.
(4) Appearance of erythema nodosum leprosum was observed 11 % in group (a) and 37% in group (b).
(5) Mitsuda reaction showed no change.
(6) Rate of sedimentation of RBC improved 44%, staitionary 28%, aggravated 28%.
(7) Bacteriological examination of skin, diminution of bacilli in number or degeneration of morphology: 17% in group (a).
(8) Liver function test showed no change.
(9) Complication : slight dizziness in 6 cases.
(10) Result in total
Group (a) Group (b)
Improvement 45% 82%
Staitionary 45% 18%
Aggravation 10% 0
In the disease which demand a long period of treatment as leprosy, it is obviously unr-easonable to draw a conclusion basing upon the data of the short period treatments. In our experiment, observation was carried out throughout 7 months which led to the following conclusion:
1) In the case of exclusive SM administration, an improvement is discernible in a cert-ain extent, using the subtoxic-maximum dosis of SM.
To enhance this effect, it is therefore postulated to minimize the toxicity of drug and to increase the possibility of long period administration.
2) Rate of improvement was higher in the case of duplicate administration of SM and promin than the independent dosage of the latter, upon which no special stress should be laid in the present status.
3) Among those cases, which showed appreciable improvement by SM, no marked res-orption of the histo-pathological change was obtainable as was observed in promin treatment.
4) Neverthless even in the case of a aggravation of nodular and infiltrative cases during the promin treatment, duplicate dosage of SM brought a definite relieves in the resorption of foci.

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This paper is dealing with the 15 cases of cerebrospinal tuberculous meningitis treated in Sagamihara National. Hosptol All cases were treated with Streptomycin (SM), and majority of which were duplicated with dosage of other anti-tuberculous drug in addition to the SM, and the results are summarized as follows
1) 4 Cases (1 of which is now under treatment) from 15 cases were survived and cured. The rate of recovery is 28.5% which would not be said necessarily superior than the data of other investigators in Japan.
2) As to the way of SM administration of the improved cases, and emphasis was laid upon the intraspinal injection than intramuscular, ; each case recieved injection of 72-130 in number and dose of not more than 20-40g in total.
And the dose of PAS which was duplicated with SM in 2 cases was 143-208g in total and of the sulfa drug was 16-70g in other 2 cases.
3) The important factors which seemed to favor the successful treatment are said to consist in following points: i. e. (1) appropriate selection of time in beginning the treatment, (2) lacking of the serious brain symptoms, (3) a definite CSF finding: markedly low level of the initial protein content, no significant fall of the initial sugar level etc. was essential, (4) and above all, the definite scarceness of lung complication was the most noteworthy factor.
4) No evidence of the impaired intelligence was discernible among these improved cases except slight spasm of upper and lower, limbs. In one case, which is of shortest observation (4 months) the CSF finding bacame quite normal.

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This paper deals with the bacteriological investigation to search the resistance of colon group pathogenic bacteria to Sulfathiasol and several antibiotics, in various status of bacteria, i. e. between newly isolated and stored strains on one hand and between the various subtypes of the same species on the other.
The strains used in this study was 18 strains of Shigella dysenteriae, one strain of Ebertella typhosa isolated this summer and 4 strains of Shigella dysenteriae one strain of Ebertella typhosa stored in this laboratory. Antibiotics was Streptcmycin (SM), Chloromycetin (CM), Aureomycin (AM), Terramvcin (TM) and Sulfathiasol (ST), Examination was performed with streaking method, and obtained the result as follows.
1) As to the antibiotic effect of above mentioned series of drugs, CM was the most potent, and decreasing in potency in the order of AM, TM and as to ST more than 10^-3 Mol was needed for the complete inhibition,
2) In comparing the resistance between newly isolated and stored strains, both were almost the same against CM, AM and TM, but against SM and ST, the isolated strains were slightly exceeded in resistance,
3) Although there were no marked difference between the various subtypes of Shigella in view point of resistance, Shigella sonne than other subtypes and E. typhosa than shigella, showed more resistance,
4) Author wish to point out the existence of a certain strain which has the normal resistance, despite failure of antibiotics administered orally, in eliminating the bacteria in stool, and also the presence of the specificity in resistance.

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This paper is dealing with the data of patho-histological studies of pleura of the 26 autopsy cases in Kiyose National Sanatorium, 11 of which were empyema cases and 16 were artif itial pneumothorax cases and we reached the following conclusion
1) According to the feature of elastic fiber -zone, the so called “Pleural-Thickning” should be classified into 2 groups, i, e, one is a thicknung of the proper pleura itself and the second is the thickened part attatched to the pleura proper a peel,
2) At first the investigation of the pleura proper was made in comparison of empyema group with the artifitial pneumothorax group, and found the thickning of the former is more predominant than the latter,
3) Then the thickning itself was devided in 4 types and also comparison was made between empy ema and pneumothorax groups ; generally to say majority of pneumothorax group showed 1-2 type and the empyema group the 3 plus 4 or 4 type.
4) After discussing the factors which seems to influence the evolution of these types of pleura thickning we reached the following conclusion; that the quality and localization of pulmonal focus, duration of artifitial pneumothorax, amount of exsudate and pus may play a important rolee in the formation of the thickning

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It is already known that the epileptiform abnormalities occur more frequently in electroencephalogram (EEG) of schizophrenia, and especially in the case of catatonia such abnormalities are even more frequent. Due to the currency of opinion that the catatonia is more common in child schizophrenia, it was of interest of the authors to investigate the EEG of child schizophrenia in comparison with EEG of adultschizophrenia. As to the method of experiment, 2 channels inkwriting-recorder connected with direct couple amplifier was used, and potential was led from frontal, parietal, and occipital area of hemisphere.
1) In the EEG of 6 children, 10-45μv, 2-4c/s waves and 10-45μv, 4-7 c/s waves were observed and 1 case showed 30-30μv, 20-30 c/s fast waves.
2) While one case of, a phrophcatatonia which showed the fast waves, has had a evidence of a predisposition to convulsion in his history, to which developement of the fast waves itself should reasonably induced, the other 6 cases of slow waves may recognized to be a abnomal pattern of schizophrenia in which no evidence of predisposition to convulsion was detectable.
3) The frequency of electroencephalographic abnormalities of schizophrenia were more predominant in children than in adult.
4) Causal correlation between electroencephalographic abnormalities and catatonia is still uncertain.

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