1) Colimycin (C. M.) is an antibiotic obtained from a species of spore-bearing aerobacilli, which were separated from the soil. It has inhibitory activity against the gramnegative bacteria. Its effects on the surgical infections caused by Escherichia coli or other intestinal bacteria are greatly expected.
2) We administered C. M. against 33 cases, of which 15 cases were acute localized peritonitis, 8 were acute diffuse peritonitis and 9 were of others (acute inflammatory intestinal diseases, empyema thoracis, and one case which C. M. was administered post-operatively upon exstirpation of anal fistula).
3) Methods of administration.: 25mg of C. M., suspended in 2 to 5cc of Aqua dest., was given intramuscularly. Daily doses varied from 50mg to 200mg, according to the degree of symptoms. Total doses reached to 250mg upto 1, 600mg in the duration of 3 to 14 days of administration. We also used C. M. by local application: i. e., 10mg of C. M. suspended in 2 to 5cc of Aqua dest., were instilled into peritoneal cavity or injected into infected wounds or operation wounds for several days.
4) Evaluation of the effects; According to the observed efficiency of C. M., we classified our caces into 3 groups. They were group A, in which C. M. was proved to be remarkably effective, group B, in which C. M. was effective and group C, in which C. M. was poorly effective. In group A, fever was alleviated and leukocytosis was mitigated within 3 days. In group B, symptoms seemed to be lessened compared to that of cases without C. M. treatment. We made comparative studies of two groups, of which one group was single C. M. group and the other group was given combined administration of antibiotics or operative measures and C. M.
5) Results: The therapeutic effects of C. M. are summarized in the following table:
6) Since acute abdominal infections are of various etiology and take complicated courses, chemotherapy must have inhibitory activities against any kinds of bacteria, especially against intestinal bacteria. Therefore, we consider that C. M. combined with other antibiotics may give better results than in case C. M. was solely used. However, our experiences were not satisfactory enough to confirm that. Notwithstanding the great progress in the chernotheiapy, operative measures still remain as the major procedures in the treatments of acute diffuse peritonitis. However, in case of local peritonitis, a subsidary treatments became generally an accepted ones, so the use of C. M. shall be reasonable treatment.

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We intended to examine the contents of hemoglobin, total serum protein, serum albumin, γ-globulin, albumin-globulin ratio and to make thymol test. Several supplementary experiments on the quantitative measurements of hemoglobin and on the thymol test were carried out. In the next place, these tests were tried upon normal persons. The hemoglobin content was measured in the tuberculin negative and positive group, respectively. Hemoglobin and serum proteins were then measured in tuberculous patients.
1. Methods: Cyan-methemoglobin method was used in the measurement of the hemoglobin content. The reagent, consisting of potassium ferricyanide, potassium cyanide and distilled water, was mixed with 1/100 volume of blood. The extinction point (E) was determined by Pulfrichs photometer.
Hemoglobin content (g/dl)=E×100×0.304
The salting-out method, based upon the Biurett reaction, was used to measure the total protein, albumin and γ-globulin. Luminal was used instead of the customary Veronal in the thymol test.
2. Results.
1) The cyan-methemoglobin method accorded within 0.6g/dl (maximum) with the copper sulphide method as well as with the Van Slyke method. There were little systematic errors. Better results were usually obtained when the test fluid had been centrifuged before comparison with the standard.
2) Our own thymol test (use of Luminal instead of Veronal) gave equal results compared to the hepatosulphalein test, and was better than the original Veronal method. The thymol sedimentation test was more sensitive when temperature became low. The optimum temperature was around 20 degrees C.
3) These examinations were carried out on normal persons.
4) There were no significant differences of hemoglobin content in the tuberculin negative, the doubtfully positive, the positive and the primary positive groups.
5) (a) In mild cases of TB, albumin-globulin ratio was normal or somewhat low; total globulin was somewhat high; γ-globulin was normal or somewhat high and thymol test was normal. (b) In moderately advanced cases, hemoglobin, albumin and albumin-globulin ratio was low; with a few exceptions; total globulin was high in half of the cases while in a few cases it was low and in others it was normal; γ-globulin was normal except in one thirds of the cases which gave higher values; thymol test was high values in the majority of the cases. (c) in far advanced cases, hemoglobin, albumin and albumin-globulin ratio were low; total globulin was low in half of the cases, while in the remaining cases, those showing higher values were two times as much as the normal value cases; γ-globulin was generally high; thymol test was high value in three fourths of the cases, while the remaining cases gave normal values.

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Not only medical but also psychological investigations are important in the diagnosis and treatment of pulmonary tuberculosis patients. We conducted the extroversion-introversion test (according to Awaji's method), the will- and temperament-test (according to Kirihara-Downey's method) and the test of autonomic nerve functions (according to Wenger's method) upon the pulmonary TB cases hospitalized in Saishunso.
The results were summarized as follows;
1) Characters of tuberculosis patients were more or less introversive than that of healthy person.
2) Characters had some co-relations with autonomic nerve functions, i. e., active or aggressive characters were more or less para-sympathicotonic and thoughtful characters were more or less sympathicotonic inclinations.

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The effects of the antituberculous preparations upon the rate of growth of tubercle bacilli were observed, by various grades of concentrations of each drugs and by hours, i. e., 1, 2, 3, 6, 12 and 24 hours. The following results were obtained.
1) INAH, DSM, PAS, TB₁ had remarkable activities of inhibition of the growth of tubercle bacilli, by any grades of density tried. INAH showed the strongest effect, PAS cane in the 2nd order and DSM, TB₁ took the next places.
2) The inhibitory activities upon the rate of growth of tubercle bacilli within 6 hours were not remarkable, while by 12 hours the delay of the rate of growth of tubercle bacilli increased remarkably.

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