Systematic observations were conducted upon the peripheral blood pictures in 40 cases of hook-worm disease and the bone marrow pictures in 14 cases, from Aug. 1948 to Jan. 1950.
Most of the cases represented microcytic hypochromic anemia, eosinophilia, gastric hypacidity and anacidity, as mentioned by other authors. Attention was given to erythropoetic series, especially maturation curves of erythroblasts and reticulocytes (Setsuda), in the observation of the bone marrow pictures.
The results of our observations suggested the disturbance of maturation, especially, in the erythrocytes system in hook-worm disease.

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Among the bacillary dysentery cases treated with tetracycline, 57 cases, whose stool was tested to be of large number of cocci especially staphylococci, were selected and were studied in order to know the changes in the intestinal bacterial flora and their relationship to the character of stool. The staphlococci, enterococci and proteus organisms isolated from them were subjected to the examination of drug-resistances.
1.) The presence of many Gram-positive cocci in remarkable decrease or absence of Gram-negative rods in stool was observed in patients during the period of drug-administ-ration and within 2 days after the cessation of the chemotherapy. Later on, gradual decrease of cocci and increase of proteus or coli group organisms were observed, and finally the coli group organisms predominated in number.
2) Seasonal change in the occurrence of proteus group was observed; i. e., among 31 cases, in which proteus appeared in stool, continuous presence of the proteus for 4 months. from July to October was observed in 29 cases.
3) There, seemed to be no relationship between changes in the intestinal bacterial flora and the character of stool in the light of the fact that pathologic stool character was observed in 42 cases out of 57, in every stages of bacterial floral changes.
4) Symptoms due shifts in intestinal bacterial flora were not manifested in the cases reported herein, but the fact, that the organisms isolated from our cases were shown to be resistant to various antibiotics, would suggest the difficulties of chemotherapy when these symptoms are encountered.

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For the measuring of intra-uterine pressure at labor, the authors made an improved apparatus which is made cf strain gauges and amplifiers. Two kinds of receptor, by which the intra-uterine pressure is directly received, were devised : one is bougie type and the other is catheter type. The former is a long rubber tube of which head is spherical and has the strain gauges in it. Wires for gauges are lead through the canal of the tube. This rubber tube is inserted into uterus between uterine wall and fetal membrane through the os uteri. The position of the head of tube in uterus is ascertained by x-ray photography. The catheter type equipment is a metal cylinder which is divided by a thin diaphragmatic membrane into upper and tower chambers. One strain gauge is pasted at the bottom of the surface of diaphragmatic membrane and the other one at the wall. The upper chamber is filled with amniotic fluid through a polyeteylene tube which is inserted in uterine cavity. Changes of intra-uterine pressure in accordance with contraction of uterus are transported to strain gauges. AC bridge circuit is arranged with the two strain gauges in the receptors and two constant resistances. The transported pressure to strain gauges is amplified as the potential changes and recorded.
The electromyograms of abdominal muscles were simultaneously recorded, thus the activity of the muscles was shown.
In case of normal labor, intra-uterine pressure followed by uterus contraction increased to 70 80 mmHg in the first stage and more than 100 mmHg in the second stage. The effect of abdominal pressure to intra-uterine pressure was not seen in the first stage but was seen in the second stage, conspicuously.
Administration of Oxytocine increased the intra-uterine pressure. Trichlorethylene and analgesics was not effective,

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The authors have performed thoracoplasty in 208 cases, from Aug. 1949 to Dec. 1952, and have drained the wound-exudate by employing aseptic open drainage with gumidrain at three times in 24 hours, upon 106 cases in the first stage of thoracoplasty and upon 102 cases in the second stage. Drained exudate was 329 cc in the average by the first stage of thoracoplasty and 183 cc by the second. As a result, it was observed that the exudate was about 90% “successfully” drained off in 24 hours, and judging from the composition of the exudate, post-operative bleeding is likely to happen. We could not find any significant relationships between the bleeding time, the coagulation time, blood loss during the operation, and operation time. As for protein contents in the exudate, decrease of serum protein was observed and the decrease was in proportion to the time. It took 3 weeks (in some cases, more) until the recovery of serum protein to the pre-operative rate. Sedimentation rate of red cells recovered to the rate of pre-operation in 3-4 weeks, and the body temperature became normal by 4th or 5th post-operative day. We could not find any fever-signs in the resorption processes of haematoma. We could not find tubercle bacilli or other bacilli in the exudate, and could not observe post-operative suppurative inflammation, owing to the use of penicillin-G. We could not find post-operative bleeding, post-operative collaps due to loss of fluid, or rapid re-expansion of lung after operation. Negative tubercle bacilli in sputa after operation was in the 80% of all the cases. No fistula at area of gumidrain and no other post-operative complications, except slight woundpains on the first post-operative night was experienced. From the results of our studies, compression of lung caused by post-operative haematoma seemed to be insignificant, and general and clinical symptoms recovered rapidly by the use of open drainage.

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The authors investigated 29 cases of pulmonary TB that became “opaquec” in the whole lung-fields of one side and showed interesting findings in x-ray tests.
Out of the 29 cases, number of male was 13 and that of female was 16.
Appearance of the opaque lung was more frequent in the left side; 28 cases in left side and 1 case in right side.
By the investigation of their bronchus in 22 cases, stenosis was found in 18 cases and ectasy in all cases.
Vital capacity was under 2, 000 cc in all cases. In 18 cases, it was under 1, 500 cc and among these cases, 2 cases were under 1, 000 cc. The vital capacity was remarkably decreased in opaque lung compared to the opposite side.
By the investigation of E. C. G. in 21 cases, right ventricular hypertrophy was found in 1 case and incomplete right bundle branch block in 8 cases.
Subsequent to the thoracoplasty in 11 cases, the result of the test of tubercle bacilli for more than one year after the operation gave the following results; negative in 5 cases and slightly positive cultures in 4 cases.

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Instead of the currently used heated and solidified egg-media, in drug resistance test of tuberculous bacilli, the author, using blood agar penicillin media (modified Tarshis media), which is easily manufactured and highly sensitive in bacilli detection, togetherwith Ogawa's media as the control, conductedd the present study.
Resistances against streptomycin (SM), para-aminosalicylic acid (PAS) and isonicotinic acid hydrazid (INAH) were measured through direct method by using the TB patients' sputa. Resistances of the strains isolated from the sputa against these drugs were measured through indirect method. Pre-treatment of the sputa was done by tri-sodium phosphate method. Comparison was made in modification of drug's power-value in the media and extent of growth in both media for every resisting bacilli. SM's power-value in the media was measured physiologically, while that of PAS and INAH were measured by chemical measurement. Growth of resisting bacilli in both media was tested, by using human type TB bacilli (H37Rv strains), on its sensitive original strains and each of SM, PAS and INAH resistant variants. The results obtained are as follows;
1) As for resistance against dihydrostreptomycin, no marked difference was observed between the modified Tarshis media and Ogawa's media, containing a double volume of DHSM.
2) Resistance against PAS appeared with less extent in the modified Tarshis media than in Ogawa's media, containing the same amount of INAH.
3) Resistance against INAH appeared in higher extent in the modified T arshis media than in Ogawa's media, containing the same amount of INAH,
4) Practically, no change was observed in the drug power value of DHSM, PAS and INAH, in the modified Tarshis media. On the contrary, decreases of 43% in DHSM, 74% in PAS and 82% in INAH were observed in Ogawa's media.
5) In the test using human type H37Rv strains, it was observed that INAH resistant bacilli showed a better growth in the modified Tarshis media than in Ogawa's media, and SM resistant bacilli, compared with the sensitive bacilli, showed a better growth in the modified Tarshis media.
6) In the modified Tarshis media, the drug power-value is accurate, and the media is suited to the growth of resistant bacilli, (resistance against INAH can be observed at early stage). Moreover, the media is manufactured very easily, thus, it is highly suitable in the test of drug resistance of tuberculous bacilli.

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The present paper deals with the bilateral artificial pneumothorax in 128 cases of bilateral pulmonary tuberculosis at the National Sanatorium Muramatsu Seiranso for seven to eighteen years.
Of the 128 cases, 62.5 per cent improved, 21.1 per cent unchanged and 9.4 per cent aggravated, in the radiological diagnosis. According to the radiological diagnosis, the results of bilateral pneumothorax were better than that of unilateral pneumothorax in bilateral pulmonary tuberculosis while the former were inferior to the latter in unilateral tuberculosis. Tests of tubercle bacilli in sputum became negative in 42, 1 per cent of the total cases.
Late results by follow-up for seven to eighteen years were investigated: 29.7 per cent of the all cases were living, 9, 4 per cent were under medical treatment, 43.8 per cent died, and 8.6 per cent had thoracoplasty, and 86 per cent were not followed. In bilateral pulmonary tuberculosis, roentgenographic results of bilateral pneumothorax were better than that of unilateral pneumothorax, but late ressults and rate of disappearance of tubercle bacilli in sputum of bilateral pneumothorax were no better than that of unilateral pneumothorax.

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