We have been carrying out research to elucidate an unexplained function, the so-called "pyramid power", of a pyramidal structure (PS) for 13 years from October 2007 to the present, September 2020, at the International Research Institute (IRI). Until our work, there were few reports that presented statistically significant results regarding unexplained functions of the PS. For experiments, we made the PS that the test subject could enter. We used edible cucumber sections (Cucumis sativus'white spine type') as a biosensor to detect the unexplained functions of the PS. The biosensors were placed on the PS apex, and two types of detection experiments of a pyramid effect near the PS apex were conducted by analyzing the released gas concentration. (i) The first type was conducted in a state where the test subject might have some influence on the PS. (ii) The second type was conducted in a state where the subject's influence on the PS was excluded. In addition, we considered that the experiment of type (i) had three different influences exerted by the test subject on the PS as follows: (i-1) when the unconsciousness ("force type I ") of the test subject who was more than 6 km away from the PS affected the PS; (i-2) when the test subject's condition ("force type II") during meditation inside the PS affected the PS; and (i-3) when the reaction of the PS to "force type II" continued after the test subject left the PS. The experiment of type (ii) was conducted in a situation where the test subject did not enter the PS for at least 20 days or longer. From the results of (i-1), (i-3) and (ii), the existence of unexplained functions of the PS, "pyramid power" was demonstrated with high statistical accuracy. From the results of (i-1), the pyramid effect that was considered to correspond to the unconscious change from the sleeping state to the awake state of the test subject 6 km or more away was detected (1% significance). From the results of (i-3), the pyramid effect with a delay was found for over 10 days after meditation (p=3.5×10-6; Welch's t-test, two-tails, the following p values are also the Welch’s t-test values). The pyramid effect with delay could be approximated very well by the theoretical curve calculated from the model of transient response phenomena. On the other hand, the pyramid effect has not been detected so far from the results of (i-2). However, it is quite possible that the pyramid effect during meditation by the test subject inside the PS will be detected by increasing the number of data in the future. From the results of (ii), the pyramid effect due to the potential power of the PS was detected (p=6.0×10-3). Furthermore, it was clarified that the potential pyramid effect for the upper and lower layers of the biosensors stacked in two layers at the PS apex was different, and the pyramid effect for the upper layer biosensors was greater than that of the lower layer (p=4.0×10-7). The results obtained so far through rigorous scientific experiments and analyses are the world's first research results demonstrating the existence of the pyramid power. We expect that this achievement will open up a new field of science and contribute to the development of a wide range of application fields.

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In 2020, the International Society of Life Information Science (ISLIS) celebrated its 25th anniversary. Unfortunately, the 49th and 50th Life Information Science Symposia, planned in 2020, were canceled because of the new type corona virus outbreak. Planned presentations were published only in the Journal of ISLIS. However, other ISLIS activities are proceeding as scheduled. The book Human Potential Science II will be published this year; all are marking this anniversary as a big leap. ISLIS together with the International Research Institute (IRI ), which has produced numerous research results in this field in its sibling organizations, will found the IRI – "o;Human Potential Science Institute "o; (tentative name). There is a plan to make it the world's best institute in this field. Along with joining us for these commemorative activities, we would like to obtain your cooperation through planning, collaboration, and recommendation of researchers and human resources from various fields. For this reason, we have already rented more space at the current headquarters, and we are also promoting the recruitment of new IRI staff members. In addition, the construction of a new headquarters building has begun with the aim of completion in the summer of 2021 on a location that is a 5-minute walk from Inage Station in Chiba City, Japan. The 25 years of progress for the ISLIS and the Promotion of "o;Human Potential Science"o; since the society's foundation in 1995 are reviewed here. ISLIS has sought and continues to seek the realization of the paradigm shift from material-oriented science and technology to a new paradigm including the consciousness, spirit and mind through research based on empirical and positive scientific methodologies, and consequently, to promote the development of health, social welfare, and education as well as social and personal peace of mind, and to contribute to the making of a peaceful world, at one with nature. Since the foundation of ISLIS, Life Information Science Symposia have been held 50 times and issues of the Journal of International Society of Life Information Science (Journal of ISLIS), totaling more than 6,000 pages of research papers and reports, have been published regularly twice a year. ISLIS held the "o;Human Potential Science International Forum"o; in Chiba, Japan in 2002, the "o;International Conference on Mind Body Science"o; in Seoul, Korea in 2004 and the "o;7th Psi Meeting"o; in August 2011 co-sponsored by ISLIS and the Facludades Integradas Espirita (Curitiba, Brazil). ISLIS published the book Human Potential Science in 2004. Existences of many anomalous phenomena have been proved scientifically. However, principles of anomalous phenomena have not been clarified yet. More scientific studies about them are needed. The 51th Symposium will be held on March 13-14, 2021 at Toho University Medical School in Omori, Tokyo. ISLIS has 11 information Centers and about 180 members in 15 countries.

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The 'life field' is the destination of both medical treatment and curing. Humans, like all living things, undergo 'nice aging' every day through four stages, birth, aging, getting sick and death, and one day they integrate life and death. The ultimate goal in holistic medicine is to support this integration.

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The Society for Scientific Exploration (SSE) congratulate the International Society of Life Information Science (ISLIS) on 25 years of outstanding science. Happy 25th Anniversary! The study of scientific anomalies has made constant progress in research and recognition in recent years. Acceptance has intensified in the general population and increasingly penetrated the minds of many mainstream researchers; especially younger professionals. Inter-disciplinary collaborations and societies like the SSE are helping to drive discovery and understanding. A shift is occurring from validating that anomalies are real; to second-order exploration of mechanisms.

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