The effect of low level laser irradiation (LLLI) was studied on cultured clonal bone cells, the RJC line. The bone cells were exposed to laser beams of various wavelengths (632.8, 635, 650, 670, 780, and 830 nm) using several energy densities. DNA synthesis in the treated cultures was evaluated by measuring the tritium-labelled thymidine uptake. A significant increase in DNA synthesis was observed at the wavelengths of 632.8, 635 and 830 nm, depending on the energy density level. A decrease was found at 780 nm. These findings suggest a possible therapeutic use of LLLI in the process of bone repair.
The utility of low reactive-level GaAlAs semiconductor laser therapy for chronic pain was evaluated in a double-blind clinical trial in 82 patients. Results obtained were also compared to those reported in 8 other double-blind studies found in the literature. Subjective symptoms were improved in 38 of 51 patients (efficacy rate: 75%) in whom a semiconductor laser system (output 100 mW, wavelength 810 nm) was used, while the improvement was noticed in only 4 of 31 patients (efficacy rate: 13%) in whom a sham laser system was employed. The difference in the efficacy rate between the two groups was significant. Skin temperature increased significantly in the laser treatment group. No significant differences were found among the efficacy rates of other low-level laser therapy systems reported on in the literature despite differences in output and wavelength used.
The SuperLizer™ (SL) is a linearly polarized broad-band near-infrared light source which can deliver a combination of phototherapy and infrared mediated heat therapy in a noninvasive manner. The present study examines the therapeutic effect of SL treatment on Bell's palsy. Fifty patients with Bell's palsy were the subjects of the study and they were randomly allocated to two groups. Group I consisted of 25 patients treated with SL radiation and oral prednisolone administration. Group II consisted of 25 patients treated with oral prednisolone administration alone. The effect of treatment was assessed with electroneurography (ENoG), coupled with the 40 points evaluation scale proposed by Yanagihara. There was no significant difference in Yanagihara's scores and ENoG between groups I and II three months after the onset of the disease in those patients with less than 50% neural degeneration. In patients with more than 50% degeneration, however, Yanagihara's score of 31.7 ± 2.1 (mean ± SEM) in group I was significantly higher than the 25.5 ± 2.4 score of group II at the same post-onset period. The group I ENoG score of 51.4 ± 4.2% was also significantly higher than the 43.0 ± 3.6% score of group II at the three month post-onset period. We conclude that SL radiation combined with prednisolone is a more effective treatment than prednisolone alone in Bell's palsy patients with more than 50% degeneration.
A girl delivered at 29 weeks gestation developed a left-sided pneumothorax which required chest drainage. Electrophysiological studies showed ipsilateral phrenic nerve injury and an ultrasound scan confirmed diaphragmatic paralysis. She was dependent on mechanical ventilation for 31 days. Laser therapy (HeNe, 35 mW) was applied transcutaneously for 45 minutes each day for 14 days to the left side of the neck at the site of the anatomical projection of the phrenic nerve. This resulted in restoration of phrenic nerve activity.
Patients with a variety of nail disorders were treated with diode low reactive-level laser therapy (LLLT). Three representative cases are presented. Case 1 was a 28-year-old Japanese female with idiopathic twenty nail dystrophy. She was treated over one year with 79 days of LLLT. After LLLT, the rough nail surface on all the fingers improved remarkably. Case 2 was a 53-year-old Japanese female with green nails. She was treated over four months with 22 days of LLLT. The greenish color of the nail plates completely disappeared following LLLT. Case 3 was a 51-year-old Japanese male with longitudinal ridges, distal interphalangeal (DIP) joint arthritis and non-allergic drug eruptions. He was treated over about nineteen months with 94 LLLT sessions. After treatment with LLLT, the nail plate with longitudinal ridges became firm and longitudinal ridges slightly improved but his DIP arthritis improved remarkably. In all three representative cases, conventional treatments had failed to resolve the problems, which all responded well to LLLT. To date, a total of 22 patients with a variety of nail disorders have been successfully treated with GaAlAs diode LLLT. It is suggested that 830 nm GaAlAs diode LLLT should thus be added to the armamentarium of dermatologists and other appropriate specialists who see abnormal pathologies of the nails and associated conditions in the course of their practice.
The situation sometimes exists where a tooth causes excessive pain to the patient, but the diagnosis cannot be made by the dentist with the traditional methods. In these instances, application of low incident doses of laser energy can provide valuable help in detecting periodontitis in its initial phases. The patient feels a sharp pain when low incident levels of laser light are applied to the tooth. Five cases are presented, where only the use of the low level laser therapy (LLLT) made possible the identification of the problematic tooth.