岩手医科大学歯学雑誌
Online ISSN : 2424-1822
Print ISSN : 0385-1311
ISSN-L : 0385-1311
21 巻, 2 号
選択された号の論文の13件中1~13を表示しています
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  • 平賀 三嗣
    1996 年 21 巻 2 号 p. 136-152
    発行日: 1996/08/30
    公開日: 2017/06/05
    ジャーナル フリー

    A clinical and histopathological study was carried out on the bone invasion by squamous cell carcinoma of the lower gingiva of 40 patients who were treated at the Division of Dentistry and Oral Surgery, Kagoshima Municipal Hospital, from January 1979 through December 1994. The tumors were classified into five categories: (a) invasion confined to the alveolo-gingiva area, (b) invasion extended to buccal mucosa, (c) invasion into the floor of the mouth, (d) invasion to buccal mucosa and the floor of the mouth, and (e) invasion of retro-molars. Radiologically determined bone absorption of 25 patients (62.5%) corresponded to the histopathologically identified tumor tissues. Of those 25 eighteen showed invasive bone resorption and seven were of the pressure type. Local recurrence rate was 12.5%( 5 of 40 patients) and most of those cases had their buccal mucosa invaded at their first visit. Histologically determined cervical lymph node metastases were recognized in 10 cases (25.0%), and eight of those 10 had their primary lesions extended to the floor of the mouth. The 5-years cumulative survival rate was 60.1%. Different prognosis was found to correlate with the extent of primary tumor into the surrounding tissues and cervical lymph node metastases. The primary tumor was histopathologically examined in 26 of 40 patients. The invasion of the tumor tissue into the mandible developed either through resorption of the cortical bone or through Haversian canal. In some of the tumor tissues in the bone marrow of the invasive type reactive new bone formation was observed, but in the pressure type fibrous tissue was found between the tumor tissue and the normal bone tissue. No direct resorption by the tumor tissue was recognized in the latter type. A correlation was seen between the X-ray finding of the bone resorption and the histologic extension of the tumor. This suggests that the radiological finding provides useful information to decide on an appropriate operative procedure for mandibulectomy.

  • 染井 宏祐, 大江 政彦, 栃内 明啓, 依田 淳一, 山内 禎, 三浦 廣行, 石川 富士郎
    1996 年 21 巻 2 号 p. 153-163
    発行日: 1996/08/30
    公開日: 2017/06/05
    ジャーナル フリー

    We investigated the effect of pentobarbital and diazepam on activities of GABA-receptor, using current clamp and voltage clamp methods. Perfusion of GABA was applied to the ganglion cells of Aplysia kurodai to induce the activities of GABA-receptor. GABAA-receptor was used in this studies. The GABA-induced Hcl-type response was suppressed by picrotoxin and bicuculine which had been antagonist of GABAA-receptor. The GABA-receptor of this type is called the GABAA-receptor. We used to do this experiment GABAA-receptor. Both pentobarbital and diazepam with the lower concentration (10-6M) enhanced Cl--dependent hyperpolarizing response to GABA. However, pentobarbital and diazepam with the concentration of above 10-5M suppressed Cl--dependent hyperpolarizing response to GABA. The mode of suppression was studied by plottings dose-inhibition curve for GABAA-type of receptor activities. The curve showed no shift in either direction with increase in GABA. These findings indicated that pentobarbital and diazepam suppressed the GABAA-receptor with noncompetitive mode.

    These results suggest that neither pentobarbital nor diazepam compete with GABA for common binding site of the receptor, but it bind to a certain allosteric site, which controls the opening ionic channel, particularly for Cl-.

  • 青村 知幸
    1996 年 21 巻 2 号 p. 164-176
    発行日: 1996/08/30
    公開日: 2017/06/05
    ジャーナル フリー

    It is known that local anesthetic lidocaine displays diphasic effects, inhibition and stimulation, in a dose-dependent manner on the symptoms in the central nervous system. The purpose of the present study was to investigate whether lidocaine exerts influence on brain monoamine or not. The levels of noradrenaline, 3-methoxy 4-hydroxyphenylglycol, dopamine, 3, 4-dihydroxyphenylacetic acid, homovanillic acid, serotonin and 5-hydroxyindoleacetic acid in the cerebral cortex, hypothalamus, corpus striatum and hippocampus of mice treated with lidocaine. The metabolites were examined using the method of high-performance liquid chromatography with electrochemical detection. The mice were injected subcutaneously with lidocaine at 4,20,40 or 80 ㎎/㎏, and killed 0,5,10 and 60 min after the administration. Next, their brains were removed and divided according to the text. The levels of metabolites of brain monoamine in mice receiving 20 ㎎/㎏ lidocaine showed a significant decrease compared to those in the control group. The levels of metabolites of monoamine in some brain areas of mice receiving 40 ㎎/㎏ lidocaine of a non-convulsant dose showed an increase 60 min after the administration, whereas those in mice receiving 80 ㎎/㎏ lidocaine of a convulsant dose showed a tendency to increase, compared to those in the control group. In the present study, it is clarified that the metabolism of monoamine is inhibited with a non-convulsant dose below 40 ㎎/kg of lidocaine and stimulated with a covulsant dose of 80 mg/㎏ lidocaine, although lidocaine has no influence on the levels of noradrenaline, dopamine and serotonin in mouse brain. Moreover, it is found that the magnitude in metabolism of monoamine shows diphasic pattems, depending on the dosage of lidocaine and the lapsed time after administration.

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