岩手医科大学歯学雑誌
Online ISSN : 2424-1822
Print ISSN : 0385-1311
ISSN-L : 0385-1311
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26 巻, 1 号
選択された号の論文の13件中1～13を表示しています
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研究
  • 担癌マウスのテロメラーゼ活性に及ぼすシスプラチンの影響
    小林 礼樹
    2001 年 26 巻 1 号 p. 23-32
    発行日: 2001/04/28
    公開日: 2017/03/25
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.26.1_23
    ジャーナル フリー
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    Telomerase is an enzyme that adds TERT proteins and telomere repeat sequences to the end of chromosomes that make up RNA sub-units. This enzyme participates in the proliferation of cell division. Not found in normal tissues, high activity is shown in malignant tumors and tissues related to generative cells. This study analyzed the influence exerted on telomerase activity (TA) by anticancer agents and examined the utility of TA as an index of anti-tumor effects. It also examined c-myc involved in the TA mechanism, bcl-2 involved in apoptosis inhibition and the emission of each mRNA. In our a results, TA was not detected in normal mouse skin tissue, but high activity was observed in the mice’s carcinoma tissue within the squarnous cells. Also, on observing significant rises in the enhancement of tumors by TA, it appears to be deeply involved in the growth of cancer. With the administration of cisplatin, TA falls off significantly and the growth of tumors is inhibited. This shows that TA may be useful as an index for the anti・cancer effects of cisplatin. Myc proteins are involved in the transcription factor of tert genes. In this research the reduction in emissions of c-myc mRNA through the administration of cisplatin is shown in the involvemellt of TA of Myc proteins. Also, our resuits suggest that tumors may tend to reduce when restrained by apoptosis through reductions in bcl-2mRNA emissions.
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  • ブタ肺動脈における低酸素性肺血管収縮の発現機序に関する検討
    ― 特に血管内皮細胞及びNOとの関係について ―
    佐藤 裕, 久慈 昭慶
    2001 年 26 巻 1 号 p. 33-43
    発行日: 2001/04/28
    公開日: 2017/03/25
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.26.1_33
    ジャーナル フリー
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    1. Hypoxic pulmonary vasoconstriction (HPV) plays an important role as a physical regulator in matching pulmonary perfusion to ventilation preventing systemic hypoxemia. But its precise mechanisrn is unkown.
    The aim of the present study is to investigate the cellular mechanisms and potential mediators involved in hypoxic constriction of porcine pulmonary arteries.
    2. Pulmonary arteries (internal diameter 2-3mm) were isolated from porcine lungs, and loaded with fura-2/AM, a Ca2+. indicator dye、 These artery rings were suspended in an organ chamber flooded with physiological salt solution on a microscope stage of a Ca2+ imaging spectrofluorimetric system. The light emission ratio of fura-2 for measurement of changes in intracellular calciurn levels ([Ca2+]i) and the isometric tension of the ring were measured simultaneously. Hypoxia was induced by flooding the reserved chamber with 95%N2 and 5%CO2 gas mixture.
    3. Hypoxic constriction and increases in [Ca2+]i were observed in the endothelium-intact rings under precontraction with 10-6M noradrenaline. In contrast, there were no hypoxic changes under precontraction with 90mM KC1.
    4. In the endothelium-denuded rings which were not relaxed with acetylcholine, hypoxia caused no changes in constriction and [Ca2+] i
    5. Hypoxic vasoconstriction of endothelium-intact rings was abolished by L-NAME, an inhibitor of nitric oxide synthetase.
    6. These results suggest that hypoxic constriction of isolated pulmonary artery of porcine lungs is induced partially by inhibition of the release of nitric oxide from the endotheliurn.
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症例
  • 未萌出下顎第二小臼歯が筋突起下方まで移動した症例について
    工藤 直樹, 佐藤 和朗, 清野 幸男, 三浦 廣行
    2001 年 26 巻 1 号 p. 44-49
    発行日: 2001/04/28
    公開日: 2017/03/25
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.26.1_44
    ジャーナル フリー
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    In the process to permanent dentition, when the same teeth on the right and left sides erupt from the gingiva at about the same time, it is not uncommon to find the mandibular premolar impacted, displaced or unerupted. However, there is the possibility of the healthy growth of dentition causing obstruction, occlusion, and maxillofacial morphology.
    We report the case of a boy, 11years and 10months old, in whom the unerupted mandibular first and second premolars migrated forward in a distal movement. The latter moved up the ramus of the mandible to the coronoid process. We considered that the distal movement caused by loss of the posterior deciduous tooth ; the warming of the gingiva and the cortical bone ; the loss of remaining arch space available for eruption ; and the imbalanced mechanism of eruption.
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