岩手医科大学歯学雑誌
Online ISSN : 2424-1822
Print ISSN : 0385-1311
ISSN-L : 0385-1311
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27 巻, 1 号
選択された号の論文の14件中1～14を表示しています
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特別寄稿
研究
  • IL-12/IL-18のマウス扁平上皮癌に対する抗腫瘍効果の検討
    北畠 顕良
    原稿種別: 本文
    2002 年 27 巻 1 号 p. 13-23
    発行日: 2002/04/26
    公開日: 2017/03/20
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.27.1_13
    ジャーナル フリー
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    Interleukin-12 (IL-12) and interleukin-18 (IL-18) exhibit strong anti-tumor effects, and induce cytokines with many similarities in function, such as induction of IFN- γ production. Concomitant administration of IL-12 and IL-18 may increase the effects. In this study, we used squamous cell carcinoma that spontaneously developed in inbred strain WHT/Ht mice. IL-12 and IL-18 were administered alone or concomitantly to tumor-bearing mice, and the antitumor effects of the cytokines were compared. As a result, the tumor growth was inhibited by IL-12 and IL-18, and prolonged survival. IFN- γ production was also increased. On measurement of cytotoxic activity and NK activity, administration of IL-12 and IL-18 increased the activities. All these effects were stronger in the concomitant administration group than the single administration groups, but body weight decreased in the concomitant administration group. The above findings suggested that the antitumor effects of IL-12 and IL-18 are exerted via T cells and NK cells, which increase IFN- γ production and enhance cellular immunity.
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  • 歯科用金属アレルギーが疑われる患者の調査
    塩山 司, 永井 成美, 古川 良俊, 石橋 寛二
    原稿種別: 本文
    2002 年 27 巻 1 号 p. 24-32
    発行日: 2002/04/26
    公開日: 2017/03/20
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.27.1_24
    ジャーナル フリー
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    Patients with metal allergy have been increasing due to various metals being used in the daily environment. Therefore, we performed patch tests in 40 patients with suspected metal allergy whose initial visit from April 1992 to march 1996. The medical route to our department and symptoms at the initial consultation at our department were evaluated in all the patients, and the association with oral metals was examined in patients positive for patch tests. The course after treatment was also analyzed. The results were as follows: 1. Fifty percents of the patients were referred to our department from the hospital affiliated to Iwate Medical University. 2. The major symptoms at the initial consultation at our department were eruptions (60.0%), oral mucosal inflammation (23.3%), and tongue pain (13.3%) 3. Patch tests were positive in 27 (67.55%) of the 40 patients. 4. According to metal elements, patch tests were most frequently positive for palladium (10 patients), followed by nickel and cobalt (9 patients each). 5. The positive metal in patch tests was consistent with the oral metal in 20 patients but inconsistent in the other 7. 6. Due to removing antigen metals in the 20 patients , three patients were cured completely, however, rest of the patients showed reduced and recurrent symptoms.
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症例
  • 間質に著しい好酸球浸潤をともなった口腔扁平上皮癌の1例
    及川 優子, 武田 泰典, 八木 正篤, 佐藤 方信
    原稿種別: 本文
    2002 年 27 巻 1 号 p. 33-36
    発行日: 2002/04/26
    公開日: 2017/03/20
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.27.1_33
    ジャーナル フリー
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    Infiltration of eosinophils io the stroma is occasionally seen in malignant tumors, and there is some relation between eosinophilic infiltration and prognosis of squamous cell carcinoma (SCC) originating in the esophagus, lung and other organs. However there are few reports of oral SCC with infiltration of eosinophils. The present paper reports a case of oral SCC with a severe degree of eosinophilic infiltration. The patient was a 71-year-old female whose chief complaint was a white lesion in her tongue. Histologic examination revealed the lesion to he well differentiated SCC with infiltration of numerous eosinophils in the stroma. A few eosinophils had infiltrated in the parenchyma. Infiltration of eosinophils was clearly demonstrated by Luna stain. Chemotherapy had effect on the lesion and surgically resected material showed complete disappearance of SCC.
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  • 閉塞型睡眠時無呼吸症候群患者に対する下顎前方誘導装置の適用
    久保田 宗次, 佐藤 和朗, 森岡 尚, 中野 廣一, 櫻井 滋, 井上 洋西, 三浦 廣行
    原稿種別: 本文
    2002 年 27 巻 1 号 p. 37-43
    発行日: 2002/04/26
    公開日: 2017/03/20
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.27.1_37
    ジャーナル フリー
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    Upper airway obstruction by the tongue occurs frequently in patients with obstructive sleep apnea syndrome (OSAS). Consequently, eliminating the collapse of the pharyngeal structures and reducing the air resistance in the cavity of pharynx could lead to the improvement of respiratory disturbance during sleep. This paper reports a clinical trial of the mandibular advancement device (MAD) for the conservative treatment of OSAS. In this case, the MAD moved the mandible to an anteroinferior position, and advanced the root of the tongue and the soft palate. In addition, middle and inferior airway space were remarkably increased. It appears that the reduction in the total number of apneic events and in the apnea-hypopnes index is attributed to the effect of the MAD on the oropharyngeal structures. Thus, the MAD may be an effective therapeutic alternative in patients with OSAS, and dentists could contribute to the manegement of OSAS patients.
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短報
  • 培養歯髄細胞のnodule形成におけるアポトーシスの関与
    矢菅 隆利
    原稿種別: 本文
    2002 年 27 巻 1 号 p. 44-48
    発行日: 2002/04/26
    公開日: 2017/03/20
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.27.1_44
    ジャーナル フリー
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    We have previously reported that dental pulp cells can form calcified nodules, and that apoptosis was detected around the nodules by using an in situ apoptosis detection kit. However, the relationship between nodule formation of the pulp cells and apoptosis has not yet been clarified. The purpose of this study was to confirm the role of apoptosis in the nodule formation of dental pulp cells in vitro. Dental pulp cells in explant culture originating from a patient with periodontitis were cultured from 5 to 9 limes in D-MEM. The cells were cultured for 4 weeks in the absence or presence of a Caspase-3 inhibitor, Caspase-3 /CPP32 Inhibitor-CHO, in order to examine its effect no inhibition of apoptosis of dental pulp cells. The formation of nodules by dental pulp cells was observed by phase contrast microscope in the fourth week of culture, and the total numbers of nodules in a definite field were counted. Apoptosis of dental pulp cells in nodules was detected with a Caspase-3 detection kit by FITC, and was observed by laser microscope. Statistical analysis on changes of the nodule numbers was done by paired or unpaired t-test. Results showed that the number of nodules formed in the absence or presence of the caspase-3 inhibitor increased every week during four weeks (P<0.01). However, the number of nodules in the presence of the caspase-3 inhibitor was significantly less than that of the control culture at three and four weeks (P<0.05). These results indicate that apoptosis of dental pulp cells in vitro occurres along nodule formation and precedes calcification.
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海外診療報告
  • ベトナム社会主義共和国の口唇口蓋裂患者に対する医療協力の経験について
    ― Odonto-Maxillo-Facial Center of Ho Chi Minh Cityにおける活動 ―
    杉山 芳樹, 岩淵 皐, 関山 三郎
    原稿種別: 本文
    2002 年 27 巻 1 号 p. 49-57
    発行日: 2002/04/26
    公開日: 2017/03/20
    DOIhttps://doi.org/10.20663/iwateshigakukaishi.27.1_49
    ジャーナル フリー
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    We offered medical and technological assistance to cleft lip and palate patients at the Odonto-Maxillo-Facial Center of Ho Chi Minh City in Vietnam. We visited the hospital three times in two years from December, 1996 to December, 1998. We operated on 93 patients with cleft lip and/or palate, 2 patients with craniofacial microsomia, 2 patients with cheek defect caused by noma and 1 patient with von Reckinghasen's disease. In Vietnam, there are many medical problems relating to cleft lip and palate patients, such as shortage of funds, medical disparity by regions and hospitals, insufficient numbers of oral surgeons and hospital beds for cleft lip and palate patients, and difficulty of obtaining new medical information from foreign countries. Most of these problems seemed doe to financial difficulties. For the present, medical assistance is necessary for the treatment of cleft lip and palate patients in Vietnam for the present.
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岩手医科大学歯学会第53回例会抄録
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