Three-dimensional simulation is necessary for the case that a face form is asymmetry in orthodontic treatment. Authors developed the three-dimensional measurement system which used the grid pattern projection method. And we had reported about using it for dental cast measurement. Furthermore, we applied this principle and developed the three-dimensional measurement device of a face. This report introduces the three-dimensional measurement device of the face which used the grid pattern projection method that was developed by us. And we report about clinical application of three-dimensional simulation of the face which used this device. It was difficult to predict a postoperative form of the face which was an asymmetry before. However, the patient is easy to have come to understand the change of postoperative facial form by performing three-dimensional simulation. The three-dimensional simulation was effective as a material of informed consent of the case especially that had an asymmetry facial form in orthodontic treatment.