This study seeks to predict the response of the human body in pre-crash conditions based on experiments. Low-speed frontal impact tests were conducted with small female volunteers in order to simulate the actual pre-crash conditions of a car when the pre-crash braking system is activated in an emergency situation. The pre-crash response of a small female occupant was predicted based on the experiment result. The head-neck motion was influenced by the muscle volume, which is related to the driver’s posture just before the collision.