It has been well known that the majority of fire-related deaths are due to the inhalation of toxic combustion products and carbon monoxide (CO) plays a main lethal role in fire accidents. Furthermore, hypoxia and carbon dioxide (CO
2) in the hypoxic condition have recently been shown to potentiate CO-induced death. This study was aimed at examining whether the relation between pO
2 and COHb concentration clarify the major cause for death of fire victims.
Blood gases and COHb concentration in the blood of fire victims (n=10) and the rabbits inhaled with the toxic gases (CO
2-toxic gas : O
2 5.0% ; CO
2 16.0% ; CO 1.8% ; N
2 77.2%, room air + CO gas : O
2 21.0% ; CO 1.8% ; N
2 77.2%, hypoxic condition : O
2 2.0% ; N
2 98.0%) were measured. From the relation between pO
2 level and COHb concentration of the victims and the rabbits, the major causes for death classified into 4 groups : 1) pure CO intoxication, 2) hypoxia + (CO intoxication), 3) potentiation of CO
2 in the hypoxic condition and/or potentiation of hypoxia for CO intoxication, 4) others.
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