One aspect of our research has been to investigate the relationship between bronchial obstruction and chrouic respiretory disease. Bronchial obstruction was produced in dogs, and the effects studied of verying intervals therafter using bronchoscopic roentgenologic, bacteriologic, and histologic methods. Our findings included the following.
1. Bronchoscopic changes were noted in the bronchial wall, including edema, redness and the later appearance of granulation tissue.
2. The nature and amount of mucous secreation, and the appearance and disappearance of vavious microorganismus were studied with regard to the duration of obstruction. Notably, Gramnegative rods were found to appeare only after prolorged periods of obstruction (11 weeks). Inference can be made of the effectiveness of bronchial self-toilet, with regard to mucus debris and bacteria.
Further reseach is needed to clarify there mechanismus.
3. Using the image amplifier, the foreign body reaction of the bronchial wall was studied as an influencing factor on the degree of obstruction, and the movement of the thorax and bronchial tree immediatory after insert a foreign body into the bronchus was recorded.
4. Histologic studies ware made of the bronchial foreign body recection and of the peripheral changes, such as atelectasis and emphysema.
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