I have investigated the experimental reconstruction of the trachea and bronchus in order to solve several fundamental problems.
I believe that indispensable factors for successful reconstruction are following 5.
1. Prosthesis has the lumen and maintains itself.
2. Insufficiency of Anastomosis must be avoided completely.
3. Inside of the prosthesis is to be covered with bronchial epithel immediately.
4. Degeneration, stenosis and granulation never occur after a long time.
5. Prosthesis is able to assimilate with Recipient tissue after it is put in the Recipient.
I used the Polyvinyl-Formal tissue plate and homologus aorta for reconstruction of circumferential tracheal defect in dogs.
Polyvinyl-Formal Sponge (P.V.F.) was affixed to the parietal Pleura for about 3 or 4 weeks and then there was formed a firm tissue plate by the ploriferation throngh the porus of P.V.F.
These P.V.F. tissue plates were cut into a proper size and used as the graft.
An experimental tracheal reconstruction was performed using P.V.F. tissue plate graft and homologus aorta to 32 mongorean dogs in which intrathoracic circumferential tracheal defect were made artificially about 4.0cm in length.
Bronchoscopic, macroscopic and histologic examination were performed after 3 weeks, 1 months, 3 months, 6months and one year.
The result of the examination is as follows;
1. The P.V.F. tissue plate graft was fairly well implanted and its epithelialization was done within 2 months.
2. Three cases were kept over 12 months but the stenosis, degeneration and rejection were not observed in their reconstruction of trachea.
3. The implantation of the homologus aortic graft seemed to be better than that of P.V.F. tissue plate graft untill 6 months but it showed the tendency of scar when 12 months passed.
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