巻号一覧
27 巻 (1976)
- 6 号 p. 385-
- 5 号 p. 325-
- 4 号 p. 263-
- 3 号 p. 197-
- 2 号 p. 63-
- 1 号 p. 1-
27 巻, 6 号
選択された号の論文の5件中1～5を表示しています
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発症機序奥田 稔1976 年 27 巻 6 号 p. 385-392
発行日: 1976/12/10
公開日: 2010/02/22
ジャーナル フリーThe mechanisms in airway allergy is generally considered, without any actual evidences, to include several processes. Allergen particles, after reaching the overlying mucus blanket of the mucus membrane of the air way, give a soluble fraction in the liquid phase and in this form easily penetrate the subepithelial layer and then induce allergic manifestation.
Previous studies conducted to establish experimental proof of this process have revealed the important role of allergic reaction in the mucus blanket acting as a trigger to produce the manifestation. This paper summarizes the results of these studies.
Allergic manifestation may take place in two steps. Soluble allergenic substance is eluted from allergen particle making a chemical mediator release from the basophilic cells in the mucus blanket, and the mediator released may be absorbed and thence stimulates the receptors close to the basement membrane of the epithelial layer in the nose, or both in the interepithelial space and beneath the basement membrane in the lower air way. This stimulation results in production of sneezing and secretion in the nose and bronchoconstriction, cough and secretion in the tracheobronchus through the nervous pathway of reflex. Subsquently a minute amount of allergenic substance enters into the subepithelial layer and makes mast cell degranulation and mediator released may act directly upon the secretory gland and vessels in the air way, that in addition, upon the bronchial muscles in the lower air way, and then results in the increases of swelling of the nasal or bronchial mucus membrane due to circulatory disorder and hyperaction of the gland and bronchoconstriction in the lower air way.抄録全体を表示PDF形式でダウンロード (924K) -
池口 栄吉1976 年 27 巻 6 号 p. 393-406_2
発行日: 1976/12/10
公開日: 2010/02/22
ジャーナル フリーSince the study of Tomasi et al., the roles of s-IgA on local immunity, and the localization of production and the secretory mechanism of s-IgA have been gradually elucidated. However, few studies have been made on s-IgA in the bronchial tissues.
The author employed Immunofluorescence method and Immunoglobulin enzyme method and examined the distribution and localization of several Immunoglobulins on bronchial mucus tissues obtained by bronchial biopsy, pneumonectomy or autopsy from 101 cases. Additionally, the relationships between the bronchoscopic findings and clinical experiments and above results were studied. Following results were obtained:
1) Linear brilliant Immunofluorescence of IgA was seen on the surface of mucousal epithelial cells in bronchial tissues and a small number of IgA forming plasma cells was noted in lamina propria, however, and brilliant deposit of Immunofluorescence of IgG was observed in basement membranane and in lamina propria. IgM was distributed in all layers of membrane, however, the deposit of its Immunofluorescence was relatively weak.
2) Immunofluores of s-IgA was stronger in bronchial acinal gland cells than in epithelial cells, therefore, it was suggested that bronchial glands were immunologically quite important.
3) IgA acted on infectious defence mechanisms in bronchial mucosa. On the other hand, IgG was noticed when inflammation developed inside of mucosa. This result may indicated the existence of Multi-defence system.
4) Secretory Component. (SC) was tended to be observed in tissues of chronic inflammation. Therefore relationship betwen SC and the repetition of inflammation was suggested.
5) Bronchoscopic findings of acute inflammation were closely related of the distribution of IgA in tissues, and those of chronic inflammation showed the good relationship with the distribution of IgG.
6) There was no defenite relationships between the distribution and the intensity of Immunoglobulin in bronchial tissues and the levels of Serum Immunoglobulins.抄録全体を表示PDF形式でダウンロード (2339K) -
吉田 明彦1976 年 27 巻 6 号 p. 407-419
発行日: 1976/12/10
公開日: 2010/02/22
ジャーナル フリーImmunoglobulins in the Secretions of bronchial tracts in one hundred and fifteen cases with various respiratory diseases were studied. IgE and IgA levels in nasal washings (NW), bronchial washings (BW) and serum were measured by radioimmunoassay method. These immunogloblins were compared by ratios calculated immunogloblin to total protein. IgE antibody titers in NW, BW and serum of the patients with allergic respiratory diseases as bronchial asthma and nasal allergy were also investigated.
The following results were obtained.
1. IgE/total proten ratios in NW and BW in the patients with atopic asthma and nasal allergy were higher than those in normal individuals (P<0.05). IgE/total protein ratios in NW and BW were less than those in serum.
2. IgE antibody titers in NW and BW of the patients with atopic asthma and nasal allergy were correlated with IgE levels in NW and BW (γ=0.95). However, there was no relation between IgE antibody titers and serum IgE levels in the same subjects. IgE antibody titers in NW and BW were markedly correlated with the threshold of skin reaction and nasal provocation by causal antigens.
3. IgE antibody titers in NW and serum of nasal allergy with bronchial asthma were higher than those in nasal allergy and bronchial asthma.
4. IgA/total protein ratios in NW were increased much more than those in BW in normal subjects, and various respiratory diseases, although IgA/total protein ratios in BW were higher than in NW of the patients with infectious asthma and chronic bronchitis.
5. IgG and IgM/total protein ratios in NW and BW were less than those in serum.
6. These results support the view that IgE is a secretory immunogloblin in that it is present in NW and BW in proportions greater than expected if it diffused from serum. However, IgE differs from secretory IgA in that ratios of IgE to total protein are greater in serum than in NW and BW. This difference is discussed in terms of diffusion into serum and nasal and bronchial secretions.抄録全体を表示PDF形式でダウンロード (1063K) -
市村 恵一, 椿 康喜代, 小林 武夫1976 年 27 巻 6 号 p. 420-426
発行日: 1976/12/10
公開日: 2010/02/22
ジャーナル フリーNine cases of nonspecific granuloma of the larynx were examined and treated by the Department of Otolaryngology, University of Tokyo, between the years 1973 and 1976.
All of the granuloma were confined to the unilateral posterior vocal cord; seven were sited at the right side and two were at the left. This site predominance was not in accord with most reported series saying the predominance of the left side.
There was a significant preponderance of males over females (7 to 2). Age range was from 35 to 68 with a mean age of 46.7 and majority of cases appearing in the fourth decade.
Hoarseness was the most common symptom occurring in six patients (67%), the next was sore throat. The patient waited an average of 13.6 months after symptoms began before visiting us.
There seemed to be some etiologic factors other than the minor trauma based on “the hammer and the anvil” theory by Jackson. Any minor trauma causing the damage of mucosal surface might induce granuloma formation.
Resection by cup forceps under direct laryngoscopy was mandatory. If recurred, electrocautery under microscope following it was the treatment of choice, and the effective results were obtained.抄録全体を表示PDF形式でダウンロード (622K) -
その気道狭窄が同側の気管支肺炎を併発したと思われる一例加藤 秀雄, 栗山 廉二郎, 志村 政文, 高村 研二, 高野 浩太, 北本 治, 池田 晃治, 中江 純夫, 金 有生1976 年 27 巻 6 号 p. 427-434
発行日: 1976/12/10
公開日: 2010/02/22
ジャーナル フリーWe examined an asymptomatic patient with a right retro-esophageal aortic arch for a suspected mediastinal tumor by radiographically and bronchoesophagologically.
No evidence of malignancy was discovered, however stenosis of the airway due to compression from out side were noticed around the middle part of the trachea and bilateral upper main stem bronchi, and extremely stenotic lumen due to compression from anterior and posterior with slight inflammatory signs were lacalized at the carina and right upper stem bronchus, by flexible fiberoptic bronchoscopy. Attendant pulsation of these area were also noted during examination.
These tracheo-bronchial findings were strongly suggestive as the cause of a recent episode of right middle bronchopneumonia.抄録全体を表示PDF形式でダウンロード (4518K)
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