巻号一覧
29 巻 (1978)
- 6 号 p. 337-
- 5 号 p. 279-
- 4 号 p. 239-
- 3 号 p. 185-
- 2 号 p. 71-
- 1 号 p. 1-
29 巻, 4 号
選択された号の論文の5件中1～5を表示しています
- |<
- <
- 1
- >
- >|
-
矢島 洋, 海野 徳二, 奥田 稔1978 年 29 巻 4 号 p. 239-246
発行日: 1978/08/10
公開日: 2010/02/22
ジャーナル フリーThe respiratory function was examined in patients with nasal allergy without bronchial asthma. Forced vital capacity (FVC), forced expiratory volume in one second (FEV 1.0), peak flow rate (PFR) and maximum expiratory flow volume curve (MEFV curve) were measured. The flow rates at 25% (V25), 50% (V50) and 75% (V75) of the vital capacity were calculated from the MEFV curves to detect changes in the lower airway. The measurements were carried out before and after the nasal provocation using paper disks and antigen solution.
The results were obtained as follows:
1. All the values in the normal control group were found to be within normal limits. Twelve point five percent of the patients showed a decrease in V50, while 35% showed a decrease in V25.
2. No changes were recorded when the provocation was attempted in the nasal cavity with paper disks.
3. The value of V50 decreased more than 20 per cent in 41.6% of the patients after the antigen solution was inhaled through the nose.
4. there was a decrease in the values of PFR, V75 V50 and V25 after the inhalation of the antigen solution through the mouth. In particular, a decrease in V50 was observed in 26.6% of the patients and that in V25 was in 31.1%.
Based on the above results, it was assumed that certain patients with nasal allergy without clinical manifestation of asthma had appreciable obstruction or hypersensitivity in the lower airway and should be taken as potential cases to develope bronchial asthma in future.抄録全体を表示PDF形式でダウンロード (826K) -
第1報 ラット分泌液中の Plasminogen Activator小杉 忠誠, 松尾 理, 美原 恒, 江夏 国寿, 松元 一郎, 森満 保1978 年 29 巻 4 号 p. 247-251
発行日: 1978/08/10
公開日: 2010/02/22
ジャーナル フリーIt is now known that antiprotease (protease inhibitor) exists in the nasal and tracheobronchial secretion, and such antiprotease activity decreases in acute inflammation. The present study was undertaken to clarify protease activity of tnacheobronchial secretion of rats. Protease activity measured was fibrinolytic activity using the fibrin plate method. The tracheobronchial fluid was collected from the tracheal lumen through the tracheostoma after performing the infusion of the physiological saline into the lumen and its simultaneous suction using the automatic infusion pump. The secretion obtained showed marked fibrinolytic activity in the standard fibrin plate. In the plasminogen free fibrin plate or t-AMCHA containing fibrin plate, no fibrinolytic activity was observed. Therefore, it is evident that fibrinolytic activity measured was due to the plasminogen activator activity. The gel filtration by sephadex G-50 after partial purification by ammonium sulfate showed two peaks, indicating the existence of two different activators (high and low molecular weights).抄録全体を表示PDF形式でダウンロード (556K) -
とくに鼻アレルギー, 気管支喘息を中心としたcAMP, cGMPと関連因子の検討大岡 久雄1978 年 29 巻 4 号 p. 252-263
発行日: 1978/08/10
公開日: 2010/02/22
ジャーナル フリーThe levels of plasma cyclic nucleotides (cyclic AMP, cyclic GMP) in 124 patients with bronchial asthma, 49 with various bronchopulmonary diseases and 24 normal individuals were measured using radioimmunoassay method. Various factors relating to the levels of cyclic nucleotides in bronchial asthma were also investigated.
The following results were obtained:
1. Plasma cAMP levels were higher than cGMP levels in normal individuals. Their G/A ratios were 0.15±0.06.
2. Plasma cAMP, cGMP levels and G/A ratios in patients with pulmonary tuberculosis, lung cancer and chronic bronchitis were higher than those in normal individuals.
3. The levels of cAMP, cGMP and G/A ratios in nasal washings after nasal provocation in patients with nasal allergy increased significantlyy compared with those of cAMP and cGMP, G/A ratio was dicreased, before nasal provocation by specific antigen.
4. In asthmatic patients, plasma cGMP levels during the attack were higher than those in the attack free interval (p<0.01), and plasma cAMP levels in the attack free interval were higher than those in the asthmatic attack.
5. High IgE antibody titers were well correlated with the levels of plasma cyclic nucleotides in asthmatic patients.抄録全体を表示PDF形式でダウンロード (1250K) -
中島 重徳, 山口 道也, 栗山 浩子, 大岡 久雄, 嘉山 保美, 大石 光雄, 津谷 泰夫, 石川 淳子, 岡安 大仁1978 年 29 巻 4 号 p. 264-271
発行日: 1978/08/10
公開日: 2010/02/22
ジャーナル フリーThe new anticholinergic compound Sch 1, 000 (ipratropium bromide) has been reported to be an effective bronchodilator without significant atropine-like side effects.
We evaluated the effectiveness of nebulized Sch 1, 000 in 30 patients with bronchial asthma. Pulmonary function was determined before and after Sch 1, 000 administration and aerosolized methacholine (3μg/dl) or causal allergic antigen inhalation.
Sch 1, 000 was effected to slight and moderate asthma attack. However, the effectiveness of inhibition to asthma attack was not so strong than the action of broncho-dilator by β-stimulants.
The protective effects of Sch 1, 000 on methacholine induced bronchoconstriction and allergen induced asthma were clearly observed.
These results suggest that Sch 1, 000 has not stronge effect than β-adrenergic agonicts has, while the protevtive effects to methacholine and allergen induced bronchoconstriction are distinguished.抄録全体を表示PDF形式でダウンロード (777K) -
池田 稔, 水島 昇, 佐久間 成晴, 山中 善明, 高山 乙彦, 中川 泉1978 年 29 巻 4 号 p. 272-276
発行日: 1978/08/10
公開日: 2010/02/22
ジャーナル フリーA rare case of the tracheal foreign body is reported. The patient was a 37 year-old-male who had aspirated a 100 yen coin into the subglottic space in the process of drinking. The foreign body was extracted by foreign body forceps using Jackson's direct endoscope under the neuroleptoanalgesia. A bibliographic consideration on the foreign body in the respiratory system was taken and the usefulness of the neuroleptoanalgesia at the removal of the foreign body was briefly discussed.抄録全体を表示PDF形式でダウンロード (2459K)
- |<
- <
- 1
- >
- >|