In order to clarify the inhibitory effects of corticosteroid on the histamine release in vitro with house dust antigen, intravenous administration of corticosteroid to asthmatic patients was performed and the following results were obtained.
1. Histamine release on challenge with house dust antigen was suppressed;
1) by intravenous administration of 4mg dexamethasone in 10 asthmatics. The inhibition rate was 24%, 60% at intervals of 3 and 6 hours, respectively.
2) by intravenous administration of 1000mg hydrocortisone in 5 asthmatics. The inhibition rate was 53%, 54% at intervals of 3 and 6 hours, respectively.
3) by intravenous administration of 30mg prednisolone in 5 asthmatics. The inhibition rate was 52%, 21% at intervals of 6 and 24 hours, respectively.
2. The inhibition rate reached a maximum extent in 6 hours after the intravenous administration of various corticosteroids.
3. Basophil count was reduced to a significantly low level after the intravenous administration of various corticosteroids. Eosinophil count was reduced to a significantly low level after the intravenous administration of either dexamethasone or hydrocortisone.
4. After the intravenous administration of various corticosteroids, neither released histamine levels nor whole blood histamine levels correlated with basophil count.
The above results suggest that the histamine release in vitro with house dust antigen in asthmatic patients was inhibited by corticosteroids such as dexamethasone, hydrocortisone, prednisolone.
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