Pulmonary gas exchange was investigated in normal anesthetised rabbits and dogs during high frequency jet ventilation (HFJV) and high frequency piston ventilation (HFPV) by measuring PaO
2, PaCO
2, tracheal pressure and minute ventilation (VE) by capacitance pneumograph (C. P). During HFJV (0.5-20 Hz) on rabbit, quadratic regression correlation was found between oscillatory frequency and PaO
2 or PaCO
2. The highest value of PaO
2 and the lowest value of PaCO
2 were found around the frequency of 4 to 8 Hz. The highest VE was also found on these particular frequencies. A hyperbolik regression correlation compatible with alveolar equation was found between VE and PaO
2 or PaCO
2.
Above data suggested that the blood gas value was determined by VE measured by C. P, not by oscillatory frequency. The largest VE was found between 4 to 8Hz. These particular frequencies may be associated with resonant frequency of the rabbit lung.
During HFJV on dog, linear correlation was found between oscillatory frequency and PaO
2 or PaCO
2. The value of PaO
2 decreased and of PaCO
2 increased in association with increment of frequency. Above data suggested that the response to HFJV was different between rabbit and dog.
During HFPV on rabbit, linear correlation was found between oscillatory frequency and PaO
2 or PaCO
2. The value of PaO
2 increased and of PaCO
2 decreased with increment of frequency. No clear correlation was found between VE and PaO
2 or PaCO
2 on HFPV.
In conclusion, gas exchange mechanism might be the same in HFJV and HFPV, since blood gas value was determined by VE on HFJV and by VT X f on HFPV.
Bulk flow and diffusion are main factors for gas exchange on low frequency, and augmented diffusion, circulating current (Disco lung) and bulk nondiffusive exchange mechanism may be important factors on high frequency ventilation.
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