Three cases of malignant change from precancerous lesions, two laryngeal keratoses and one laryngeal papilloma, are reported.
Case 1 was a 67-year-old man. Malignant change was recognized three and a half years after he had noticed hoarseness and laryngeal dryness. He was treated by irradiation of 5, 000rads and thereafter cancer cells disappeared.
Case 2 was a 57-year-old man. His laryngeal keratosis developed into a malignancy one year and ten months after he had recognized hoarseness and laryngeal discomfort. He was treated by irradiation of 6, 500rads, but cancer cells remained. So he underwent a total laryngectomy.
Case 3 was a 50-year-old man. Malignant change was noted in the laryngeal papilloma, which had been diagnosed one year and eight months before. As he noticed dyspnea due to papillomatous masses on both vocal cords, a total laryngectomy was performed.
According to our experience and literature review, we concluded as follows:
1) Laryngeal keratosis, especially with a reccurent tendency should be treated by a conservative surgical resection (e. g. laryngomicrosurgery). In case of malignant change, an irradiation therapy is mandatory to be done before an advanced surgical approach was performed.
2) Laryngeal papilloma should be also treated by a conservative surgical method. In this case an irradiation therapy would be contraindicated.
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