Responsiveness of airway means a hypersensitive condition of upper and lower airway to various stimuli. We measured nasal and oral respiratory resistances with rhinograph before and after an inhalation of methacholine through the nose with astograph to observe responsiveness of upper and lower airway. Subjects were 56 persons who had nasal obstruction, watery rhinorrhea and sneeze, and had an abnormal sensation at pharyngolaryngeal area.
We devided 56 subjects into four groups according to change of nasal and oral respiratory resistance after an inhalation of methacholine. Four groups are: 1) increase in both nasal and oral respiratory resistances: 33 subjects, 2) increase in nasal respiratory resistance: 11 subjects, 3) increase in oral respiratory resistance: 8 subjects, 4) no change or decrease in both nasal and oral respiratory resistances: 4 subjects.
Nasal respiratory resistance after an inhalation of methacholine increased most in the first group, and next in the second group. Oral respiratory resistance after an inhalation of methacholine increased most in the first group, and next in the third group. According to analysis of reacting curve to methacholine with astograph, a minimum dose of methacholine that caused an increase of respiratory resistance (Dmin·N) increased in order of the first group, the third group, the second group, and the fourth group. Slope signifying increase of respiratory resistance (Sd·N) decreased in the same order.
From the above observations, we obtained following results. Responsiveness of airway is located in only upper airway, only lower airway or both upper and lower airway. In these three conditions, responsiveness of both upper and lower airway is most hypersensitive. Responsiveness of lower airway is more hypersensitive than that of upper airway.
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