Two cases of laryngotracheal amyloidosis, who had been followed up for 15 and 8 years after their first treatment, were reported, and their long-term course was discussed. In Case 1, although the extent of the lesion was wide (from the supraglottic to the bronchus), the patient was followed up for 15 years after a first tracheostomy and biopsy, wearing a speech cannula without regrowth and progress of the disease. In Case 2, although the lesion was within the subglottic region, regrowth of the amyloid mass occurred after tracheostomy and endoscopic surgery. Case 2 required a laryngofissure, curettage of the amyloid, skin grafting and hyoid bone implantation, as a third operation, with no further recurrence. In the treatment of amyloidosis arising in the larynx and trachea, long-term follow-ups are needed after a proper diagnosis of the extent and progress of the lesion, as well as accurate procedures and timing of any operations.
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