JOURNAL OF THE BREWING SOCIETY OF JAPAN
Online ISSN : 2186-4012
Print ISSN : 0914-7314
ISSN-L : 0914-7314
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Volume 111, Issue 2
Displaying 1-8 of 8 articles from this issue
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  • α-glucosylglycerol contained in Japanese sake : inhibitory effect on ALDH activity
    Shuichi SEGAWA, Takahito TAKASE, Koji TAKAZUMI, Takayuki KOSUGI, Takes ...
    2016 Volume 111 Issue 2 Pages 107-116
    Published: 2016
    Released on J-STAGE: May 28, 2018
    DOIhttps://doi.org/10.6013/jbrewsocjapan.111.107
    JOURNAL FREE ACCESS
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    Ethanol is metabolized to acetaldehyde by several enzymes such as alcohol dehydrogenase (ADH), CYP2E1, and catalase. Acetaldehyde is then metabolized to acetate by aldehyde dehydrogenase (ALDH). Acetaldehyde is toxic and is suspected to be a carcinogen in alcohol-related carcinogenesis and to induce a facial flushing reaction after alcohol consumption. Some foodstuffs are reported to inhibit ALDH2 activity. However, it remains unclear whether alcoholic beverages contain any substances that influence the alcohol metabolism. In this study, we investigated the effect of Japanese sake on alcohol metabolism, especially acetaldehyde degradation, and for the first time, clarified that Japanese sake-derived α-glucosylglycerol has an inhibitory effect on ALDH activity.
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