Alternative splicing (AS) contributes to the generation of distinct mRNAs from the same pre-mRNA. This mechanism is highly conserved in eukaryotes and yields proteomic diversity. Furthermore, AS can be tissue- and developmental stage-specific and is an important process in the development of the central nervous system. Although these features suggest that AS variants contribute the complexity of the brain, the characteristics of most AS variants are unclear. Therefore, it is important to identify and examine novel AS variants in neuronal tissues to fully understand neuronal functions. We have identified a novel AS variant of murine disrupted in schizophrenia 1 (Disc1), a neural developmental gene. This variant lacks exon 2 and is named 'ΔE2'. We also show differences in the expression levels and localization patterns between ΔE2 and full length Disc1 (FL) in the murine brain. Differences in the subcellular localization patterns of both isoforms in cultured SK-N-SH cells suggest that ΔE2 has different functions compared with those of FL. Further functional analysis of ΔE2 may indicate additional roles of Disc1, and may further our understanding of the developmental mechanisms for neurodevelopmental disorders such as schizophrenia.

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China is a populous country, it is well known that there are many people who need treatment. The majority of patients are looking forward to big hospitals of urban to accept treatments. As the number of patients is increasing, the load of medical workers is more and more heavy. It is hard-won for medical workers to have a long holiday, because it will take a huge burden to colleagues. So to alleviate the mental stress has become a urgent affair instead of a long holiday. The Morita therapy is a kind of behavioral treatment which comes from Japan. It is valuable to consider whether this kind of treatment is useful for medical workers. We begin our research towards the direction of alleviating the mental stress of the hospital staff. As the core of the Morita therapy, it is important to understand the meaning of leting nature taking its course. It is impossible to alleviate the tension and reduce the incidence rate of obsessive compulsive disorder even if doing a lot of works. We advance our research based on this opinion. The fear in the obsessive concept is a difficulty in the Morita therapy. We want to provide a relaxing circumstance for patients to help them relax themselves. Thus we consider that it is impossible to help them relax by the use of music. Not all the music is available for one person. People have found that the treatment effect is related to the frequency of music. For example: some people hold the idea that listening to high frequency music does not have a good effect on people who are deeply mired in depression. However, letting them listen to the appropriate music has the effect of adjusting heart.

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Cerebrovascular disease is a kind of complications in diabetes mellitus which is induced by suger, fat and protein metabolic disorder. These series of nutrient metabolic disorder can lead to intracranial large blood vessels and microvascular lesions. About 20-40 percent of type 2 diabetes patients will suffer from cerebrovascular diseases which become the main causes of death in diabetic patients. Recently many kinds of pathogenesis have been found by researchers about cerebrovascular diseases in diabetes mellitus such as hyperglycemia, insulin resistance, endothelial cell dysfunction, abnormal lipids metabolism and so on. The major clinical manifestations of diabetic cerebrovascular diseases are asymptomatic cerebral atherosclerosis, stroke, cerebral small vessel diseases and acute cerebral vascular diseases. This article will introduce the pathogenesis and clinical features of diabetic cerebrovascular diseases in detail. We will also focus on its latest research progress.

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