The Journal of Japanese College of Angiology
Online ISSN : 1880-8840
Print ISSN : 0387-1126
ISSN-L : 0387-1126
Volume 55 , Issue 10
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Original Article
  • Ken Tsuchida, Hitoshi Goto, Munetaka Hashimoto, Daijirou Akamatsu, Tak ...
    2015 Volume 55 Issue 10 Pages 179-184
    Published: 2015
    Released: November 10, 2015
    JOURNALS FREE ACCESS
    Single-blind crossover study evaluating the efficacy of transdermal administration of glyceryl trinitrate (GTN) for intermittent claudication was performed. Eleven patients who had symptomatic peripheral artery disease (PAD) were enrolled. The patients were administered GTN tape or placebo tape on the calves of the diseased side limb. Treadmill test and answering walking impairment questionnaire (WIQ2) were required before and after 14 days of GTN administration. After 7 days of washout period, they were administered the other tape and had test as well as former period. The patients were randomly divided into GTN tape first group and placebo tape first group. All patients accomplished the whole series and did not show any side effects. The data showed no carry-over effects. Maximum walking distance (MWD) and WIQ2 score significantly increased by the administration of GTN tape. Pain-free walking distance (PWD) had a tendency to increase though that was not statistically significant. Proximal (iliac) lesion group was thought to respond to GTN tape more than distal (infrainguinal) lesion group. The transdermal administration of GTN tape was thought to improve the intermittent claudication of PAD patients.
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