The Journal of Japanese College of Angiology
Online ISSN : 1880-8840
Print ISSN : 0387-1126
ISSN-L : 0387-1126
Volume 57 , Issue 6
Showing 1-5 articles out of 5 articles from the selected issue
Review Articles
  • Eijun Sueyoshi
    2017 Volume 57 Issue 6 Pages 77-80
    Published: June 10, 2017
    Released: June 10, 2017

    Aortic dissection is sometimes lethal. Therefore, accurate and rapid image diagnosis is promptly needed to improve the prognosis. However, the image findings of complication are various. In this review, we present several cases with representative complications of aortic dissection. We also describe typical imaging findings of these complications in patients with aortic dissection.

    Download PDF (2741K)
  • Shigeyuki Kawa, Yasunari Fujinaga
    2017 Volume 57 Issue 6 Pages 81-89
    Published: June 10, 2017
    Released: June 10, 2017

    IgG4-related disease (IgG4-RD) is a recently established disease concept closely associated with elevated serum concentration of IgG4 and abundant IgG4-bearing plasma cell infiltration within affected tissues. The characteristic features of IgG4-RD can be summarized as follows: (1) systemic organ involvement; (2) the ability to involve multiple organs either simultaneously or in a metachronous fashion; (3) imaging findings of swelling, nodules, or increased organ wall thickness; (4) elevated serum IgG4 concentrations; (5) lymphoplasmacytic infiltrate within affected organs, characterized by abundant IgG4-bearing plasma cells; and, (6) favorable response to glucocorticoid therapy in most cases. IgG4 related cardiovascular diseases had been detected during systemic image analysis of other IgG4-RDs, such as autoimmune pancreatitis, and pathological evaluation of surgical specimens, such as aneurysm. At the beginning, these lesions had been recognized as wall thickening of abdominal aorta, and included in the spectrum of retroperitoneal fibrosis. Later, it was evident that these lesions showed systemic vascular distribution, such as thoracic aorta, coronary artery and iliac artery, which resulting in the proposal of the concept of IgG4 related cardiovascular diseases. Extensive studies have been done mainly by 2 approaches, pathological evaluation of surgical specimens and imaging analysis of cases with IgG4-related diseases.

    Download PDF (605K)
Original Article
  • Nobukazu Ishizaka, Yasunari Fujinaga, Ryoto Hourai, Tomohiro Fujisaka, ...
    2017 Volume 57 Issue 6 Pages 91-98
    Published: June 10, 2017
    Released: June 10, 2017

    Immunoglobulin G4 (IgG4)-related disease, that is characterized by the elevation of circulating IgG4 level and the tissue-infiltration of IgG4-positive plasma cells, can target the cardiovascular tissue, although the diagnosis of IgG4-related cardiovascular lesion is not easy owing to the substantial risk for the tissue sampling. We herein examined the serum IgG4 levels among cardiac patients. In patients who were admitted to the cardiology department (n=477) and those who underwent computed tomography coronary artery angiography (n=401), elevated serum IgG4 level (≥135 mg/dL) was found 23 (4.8%) and 17 (4.2%), respectively. However, among those with elevated serum IgG4, only two patients could be clinicopathologically diagnosed with IgG4-related disease. Cardiovascular organ involvement may aggravate the prognosis of IgG4-related disease, which in general not life-threatening. Considering that the non-negligible prevalence of high IgG4 level among cardiac patients who were not diagnosed with IgG4-related disease, however, physicians should no count too much on the serum IgG4 levels for the diagnosis of IgG4-related cardiovascular lesions, especially when histopathologic findings are not available, or when other-tissue involvement of IgG4-related disease is not apparent.

    Editor’s picks

    Download PDF (1789K)
Case Reports