The importance of sterile inflammation has been shown in the pathogenesis of cardiovascular diseases, such as atherosclerosis and myocardial infarction. We have reported that NLRP3 inflammasome plays a crucial role in the development of atherosclerosis and abdominal aortic aneurysm using mouse models. Recently, we have identified a novel E3 ligase that negatively regulates NLRP3 inflammasome activity. In this review article, we will discuss the regulatory mechanism of NLRP3 inflammasome activity by ubiquitination and the role of NLRP3 inflammasome in the pathogenesis of atherosclerosis and abdominal aortic aneurysm.
The tailoring technique, which involves partial resection of an aneurysm followed by direct suture of the remaining arterial wall, is one of the surgical options for renal artery aneurysm (RAA). We evaluated the short- and long-term outcomes of eight patients who underwent surgery for saccular RAAs using the tailoring technique. Acute kidney injury was postoperatively reported in only one patient, and no patient required hemodialysis. During the long-term follow-up period (mean, 5.3±3.6 years), renal artery stenosis, renal artery occlusion, and RAA recurrence did not occur among the patients. Aneurysmorrhaphy using the tailoring technique is an effective surgical option because of its favorable long-term outcomes.
We report a case of concomitant CEA and AVR. A 77-year-old man was hospitalized due to severe AS and severe right common carotid artery stenosis with mobile plaque. The mobile plaque was the risk factor of postoperative cerebral infarction in cardiac surgery. Therefore, we decided to perform concomitant carotid and valvular surgery. First, we exposed the carotid artery, and established CPB. The carotid artery was clamped when the core temperature was 30 degree. The CEA was performed under simple carotid arterial clamping. Then AVR was performed. Combined carotid and cardiac valve surgery is considered to be effective in such cases.