A computer program which used Excel/VBA was made so that the student who did not major in chemistry could learn concepts about similarity of molecular structure easily. By this program, it is possible to calculate Pearson correlation coefficient (
rP) and Tanimoto coefficient (
rT). From the point of view of education, both programs were done in a convenient way which plural comparison molecule cannot handle. We kept the function which changed reference value into the program which calculated
rT. The possibility that there was a concept of resolving power in similarity was suggested by the results of calculation with this function. We calculated
rP and
rT of Dioxin isomers for 2,3,7,8-PCDD with this program. It was suggested that there was good correlation between calculated indexes and TEF.
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