For the purpose of producing experimental hypertension, the ATP-ase fraction of the house-rar's kidney were administered in albino rats pretreated with DCA and salt or salt alone. The blood pressure of albino rats was elevated early after the beginning of administration of the ATP-ase fraction of the house-rat's kidney and this hypertension was irreversible even after stopping loading of salt. But in albino rats not treated with the ATP-ase fraction of kidney, while blood pressure was elevated slowly by virture of DCA, it came down after the cessation of loading of salt. The histological changes in albino rats treated with the ATP-ase fraction of kidney were degenerative and of various type in tubules, glomeruli and there were changes similar to necrotizing arteritis in arteries or arterioles in kidneys. But, in albino rats not treated with the ATP-ase fraction of kidney, only proliferation of endothelial cells of glomerular tufts were revealed.

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The author attempted to produce the arteriosclerosis in various organs in albino rats. Cholesterol, methyl-thiouracil or butter were additionally administered in the albino rats previously loaded with the ATP-ase fraction of the house-rat's kidney and DCA. Besides the vascular lesions in renal arteries as shown in the previous paper, arteriosclerotic changes were produced in the coronary, mesenteric or cerebral arteries, and, in some animals, myocardial fibrosis or cerebral demyelinating lesion were observed. Myocardium ATP-ase fraction was administered in normotensive albino rats, in combination with the loading of cholesterol, methyl-thiouracil or butter. Coronary sclerosis was produced in normotensive albino rats, but no marked vascular lesions were observed in kidney or other organs.

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It had been known that a kidney extract containing adenosine triphosphatase activity had some injurious action on the blood vessel. In the present experiment, canine kidney extract was injected intravenously for the periods of two to nine months on thirteen young mongrel dogs. In addition, small doses of butter, cholesterol suspension or methimazole were given. Histological investigation revealed sclerotic changes in the arteries of those organs including the aorta, spleen, kidney and the lung.

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The Relationship between the coronary flow and the electrocardiogram was studied by artificially changing the coronary flow through the coronary arterial catheter in dogs, without opening the chest. When the coronay flow was reduced to from 69.0% to 23.8% of the initial level, the electrocardiographic changes appeared chiefly in the S-T segment or the T wave, and they were dependent upon the degree, and duration of the artificial reduction of the coronary flow, and limited principally to the leads oriented towards the catheter-perfused area. When the base line electrocardiogram was normal or changed only slightly, the electrocardiogram showed considerable resistance against the reduction in the coronary flow. The S-T depression or decrease of the T wave in amplitude was produced by the reduction in the coronary flow and it was not so progressive under the maintained low coronary flow. When the coronary flow was restored to its initial level, the electrocardiogram, once changed, returned to the base line state. When the base line electrocardiogram was moderately or severely changed one, the electrocardiographic changes caused by the reduction in the coronary flow were complicated. The S-T elevation, the high T wave and the decrease of the QRS complex in amplitude were produced in addition to the above described changes of the S-T segment and the T wave. They were progressive and did not return to the initial state within 5 minutes, when the coronary flow was restored to the initial or a little above this level. When the coronary flow was reduced gradually, the electrocardiogram was considerably resistant against the reduction of the coronary flow and the electrocardiographic changes were not so progressive. The electrocardiographic changes were marked and progressive, when the coronary flow was reduced rapidly.

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