An electrocardiographic diagnosis of bilateral bundle branch block has been made only in rare instances. But the authors presented two cases of this sort and elucidated its mechanisms. The first case could be explained by a transient block in the left bundle branch in the presence of a permanent block in the right bundle branch. A second case is an example which completely fulfils the well-known criteria of ROSENBAUM and LEPESCHKIN.

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1 ) The impairment of urinary concentrating ability accompanied with the increment of urinary urea/non-urea ratio and the decrement of urea concentration gradient of renal tissue was observed in phenacetin fed rat. 2) Results were discussed from the view-point of urea accumulation in renal medulla.

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An extensive clinical evaluation was performed on 52 patients with transient focal cerebral ischemic attacks. During the follow up of 1 to 4 years, 27 cases developed a major stroke, indicating the importance of this condition as a prodrome of the major stroke. In a considerable number of cases, the blood pressure was elevated during an attack, which could be best explained with an increased pressure gradient between pre- and post-stenotic portion. A pathological study revealed micro-infarction in all cases autopsied, suggesting the inadequacy of the term, " transient ischemia without infarction ".

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Reports on the nervous regulation of the bronchial vascular system have been comparatively few. One of the difficulties lies in the fact that, in preparations so far proposed to measure the bronchial arterial flow directly, this flow is supplied from the systemic circulation and the autonomic nerve stimulation inevitably induces changes in cardiac action which may mask the effect of bronchial vasomotor tone change. In this study, a preparation has been deviced in which changes in bronchial vasomotor tone is directly reflected in bronchial arterial flow, and the effects of the autonomic nerve stimulation have been observed.

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As previously reported, the reno-portal venous anastomosis had curative effect on the elevated blood pressure of the renal hypertensive dogs and this was probably due to the inactivating ability of the liver to the pressure substance released from the kidney. It has also been reported that this anastomosis han no significant noxious effect on the liver function during the long period of observation. Another important problem which should be solved before this technique can be used clinically is its effect on the renal function. In the present experiments, the renal function before and after the reno-portal venous anastomosis was examined by means of renal "Clearance" in normotensive and hypertensive dogs. Experimental hypertension was produced under the modified GOLDBLATT method by constricting the right renal artery with a tantalum plate or under the modified MASUGI'S method by intravenous administration of the anti-dog-kidney-cortex rabbit immune serum in the previously left nephrectmized dogs. The anastomosis was carried out by end to side anastomosis between the right renal vein and the portal vein or to the root of the superior mesenteric vein. Blood N. P. N., and serum Na, K and Cl were measured to investigate the influence caused by such reno-portal venous shunt. Blood N. P. N., serum Na, K and Cl remained within its normal level. Adult female mongrel dogs weighing approximately 10 kg were used for the experiments. In normotensive dogs, no significant change was noted in both the blood pressure and the renal function after the anastomosis. In hypertensive dogs with constricted renal arteries, the impaired renal function showed a slight improvement after the anastomosis and that was accompanied with normalization of the elevated blood pressure. In the nephrotoxic nephritis, the renal function was compared between the non-anastomosed and the anastomosed group, after induced nephritis. In the anastomosed group, no significant elevation of the blood pressure was followed after the administration of the immune serum, whereas the blood pressure of the non-anastomosed elevated markedly. As to the renal function, however, no significant difference concerning the degree of impairment could be found between the two groups after giving the immune serum. It may be concluded that the reno-portal venous anastomosis has no significant effect on the normal kidney, whereas it has the favourable effect upon the impaired kidney function, especially when this is produced by the constriction of the renal artery.

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The purpose of this study is to clarify the influence of restrictive ventilatory impairment upon the pulmonary circulation when alveolar and blood gas composition are changed. The condition of restrictive ventilatory impairment was producted by suppressing ventilatory response due to inhalation of O₂ poor or CO₂ rich gas mixtures. The changes of pulmonary circulation and gas exchanges in this condition were compared with that without restrictive ventilatory impairment. Materials and Methods The normal dogs were used in moderately deep Nembutal anesthesia and divided into following three groups (Group I, IIa, IIb) 1) Group I ; Without restrictive ventilatory impairment ; The dogs were breathing spontaneously and not suppressed ventilatory response caused by 7% or 10% CO₂ gas mixtures. 2) Group IIa ; With moderately restrictive ventilatory impairment ; The dogs were under controlled negative pressure ventilation placed in body respirator of our design and hyperventilation caused by inhalation of 7% O₂ or 10% CO₂ gas mixtures was restricted to about twice as ventilation at rest during air breathing. 3) Group IIb ; With highly restrictive ventilatory impairment ; The dogs were under equally controlled ventilation as normal by the same way as Group-IIa and ventilatory response was completely suppressed. Pulmonary arterial and right ventricular pressures were measured by electromanometer through two catheters introduced via jugular and recorded with ECG simultaneously. Cardiac output was measured by STEWART-HAMILTON'S method. The end-diastolic volume, residual blood volume and its ratio (RV/EDV) of right ventricle were estimated by modified BING-HOLT'S method. Blood gas analysis were performed by direct method using Combianalyser (GODART) Measurement of ventilatory values and another measurements or calculation were carried of pulmonary circulation and gas exchanges were performed on each experimental group before and about 15 minutes after starting inhaltioh of 7% O₂ or 10% CO₂ gas mixtures.

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Recently there have been some trials on immunological studies on cardiovascular diseases. In myocardial infarction, a few studies have been conducted. The author directed his attention toward the attitude of serological reaction in rheumatoid arthritis as a part of the immunological examination in myocardial infarction. This paper presents the frequency of the positivity of the R. A. test, the relation between clinical features and the positive findings of R. A. test, and the mechanism of appearance of the positive factor of R. A. test in myocardial infarction. Materials and Methods Clinical materials totaled 88, consisting of 40 patients with myocardial infarction, 11 with angina pectoris, 16 with rheumatoid arthritis and 21 healthy persons as control. The materials used were sera obtained from each subject in this study and prepared sterilely. 1) R. A. Test : The reagents supplied by the Hyland Lab., U. S. A., were used for the R. A. test. In this test the quick slide method designed by SlNGER and PLOTZ and the dilution method were used. 2) Waaler-Rose Reaction modified by HELLER : Agglutination at a dilution of 1 : 64 or greater was recorded as 'positive'. 3) FII Test modified by KUMAGAI : O-group human erythrocyte was used instead of sheep erythrocyte, and the buffer to which was added human albumin at the rate of 0.5% was used. Other technique was according to the original method. Agglutination at a dilution of 1 : 200 or greater was recorded as ' positive '. 4) Gel Filtration : Serum protein was fractionated by gel filtration in Sephadex G-200. R. A. test was performed on each of these fractions. 5) Immunoelectrophoresis : This procedure was performed according to the method described by MIGITA. 6) Ultracentrifugation : A Spinco Model E ultracentrifuge was used to obtain the distribution of the protein.

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