The relation between K
2 and PHLA was studied in human subjects with special reference to clinical data determined by routine laboratory and physical examinations. The results obtained by Multiple Regressinon Analysis indicated that those factors which may contribute to K
2 variation were fasting tryglyceride level and age. There was an inverse partial correlation between K
2 and fasting trigycerided level and between K
2 and age.The first and second principal components calculated by Principal Component Analysis indicated that K
2 is closely related to obesity and hyperlipidemia, especialy hypertriglyceridemia, while PHLA related to albumin.These two components also suggested that K
2 give different clincial information from that obtained by PHLA measurement. There was no partial correlation between K
2 and PHLA.The various lipoprotein paepr electrophoretic patterns, type II
a, type II
b, type IV and normal patterns, were clearly characterized by such factors as K
2, plasma tryglyceride and degrec of obesity which has high coefficients in the first prinicipal component.
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