Nihon Daicho Komonbyo Gakkai Zasshi
Online ISSN : 1882-9619
Print ISSN : 0047-1801
ISSN-L : 0047-1801
Volume 35, Issue 2
Displaying 1-11 of 11 articles from this issue
  • F. Konishi, B.C. Morson
    1982 Volume 35 Issue 2 Pages 103-111
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
    1242 adenomas and early invasive carcinomas removed by colonoscopy at St. Mark's Hospital were studied. Among the lesions 0.5-1.0 cm, the percent of adenomas with severe dysplasia plus early invasive carcinomas (what is generally considered to be early carcinoma of the large bowel in Japan) was 8, 5%, which is a greater value than those previously reported on surgical cases. Adenomas smaller than 5 mm. showed relatively even distribution throughout the entire colon, on the other hand those larger than 5 mm showed the highest incidence in the sigmoid colon. Adenomas with moderate or severe dysplasia also showed the highest incidence in the sigmoid colon. Consequently, adenomas of the sigmoid colon are considered to have the highest risk of developing carcinoma, The greater number of adenomas per patient indicates increased cancer risk, which should be taken into consideration in the treatment and follow up of the patients with multiple adenomas. Female adenomas have slightly higher risk of developing carcinomas than male adenomas. Possible involvement of sex hormons in the carcinogenesis is suggested. Further epidemiological study, comparing British and Japanese adenomas, may produce epidemiologically interesting results.
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  • G. Nakano, T. Nakamura, K. Mogami, H. Kimura, T. Iijima, M. Arai, H. H ...
    1982 Volume 35 Issue 2 Pages 112-117
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
    This experiment was carried out to see the effect of high fat diet on the induction of colon carcinoma/adenoma in rats by N-methyl-N'-nitro-N-ni trosoguani dine (MNNG). Two groups of rats fed on two different dose of fat diet, including 11 per cent and 5 per cent of fat dose were used. Comparison of the incidences of colon adenoma between the two groups revealed a significant difference. Incidence of adenoma of the colon in high fat diet group was 81.8 per cent, wheras it was 33.3 per cent in control group (p<0.05).
    However there was no significant difference in the incidence of colonic carcinoma between them. Two cases with carcinoma in adenoma were also detected in high fat diet group.
    From these results, it was concluded that the effect of high fat diet on carcinogenesis of the colon might disappear with the more effective carcinogen itself, however it would bring light on the research of malignant change from adenoma due to the evidence of higher induction of adenoma of the colon by MNNG.
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  • T. Furuya
    1982 Volume 35 Issue 2 Pages 118-127
    Published: 1982
    Released on J-STAGE: December 03, 2009
    JOURNAL FREE ACCESS
    Plasma levels of Carcirioembryonic antigen (CEA) were measured in 60 patients with colo-rectal cancer. Measurement were also carried out in 43 controls. Plasma levels of CEA were 56.9±241.3 ng/ml (mean±SD) in the patients and 50% of them showed positive plasma CEA (>5 ng/ml). Plasma levels of CEA were 2.6±1.7ng/ml in controls and 14% of them showed positive plasma CEA. Tissue contents of CEA were measured in 30 patients with colo-rectal cancer. Measurement were also carried out in 6 controls. Content of CEA in cancer tissue was 8077.3±6118.5ng/g, whereas it was 140.1±25.1ng/g in controls.
    There was a close correlation between total amounts of CEA contained in cancer tissue and plasma levels of CEA, but not between contents of CEA contained per unit weight of cancer tissue and Plasma levels of CEA.
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  • Y. Hishinuma, I. Shibata, S. Fuziwara, A. Machii, Y. Murakami, T. Nish ...
    1982 Volume 35 Issue 2 Pages 128-136
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
    The colonic mucosa of 29 patients with inflammatory bowel diseases, such as ulcerative colitis and bacillary dysentery were studied by scanning electron microscope. Six control patients and 13 endoscopically normal patients with some intestinal symptoms were studied as well. As far as the moderate and severe cases are concerned, the removal of the mucous on the mucosal surface was attained satisfactorily by using of 5 % pluronic F 68 (surface active agents).
    The remarkable findings were deformity of the units, blurring of the furrows, deformity of the epithelial cells, enlargement of the crypts, increase or decrease of the goblet cell number and deformity of microvilli. The severity depending on the changes of microvilli was compatible with ones based on the endoscopical and histological findings. We were able to find the change of microvilli probably due to reproduction in addition to atrophy. No specific findings for each disease were noted as yet.
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  • S. Takashima, T. Kosaka, T. Uemura, H. Katayama, A. Yamaguchi, I. Kita ...
    1982 Volume 35 Issue 2 Pages 137-146
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
    We have investigated the clinical meanings of CEA in 158 cases with primary cancer of large intestine and 33 cases of recurred cancer.
    The CEA positivity was 35 % in the primary cases and 82 % in recurred cases. This suggested the possibility to predict recurrences of cancer.
    A correlation could be noted between the stage classification and the CEA positivity, but no difference was found out between stage III and N.
    It was assumed that the pathological factors exerting influences upon the CEA positivity would be the diameters, degrees of penetration, and v-factor, but not n-factor and ly-factor.
    The progress in the CEA values thronghout 3 months after the operation could be used for evaluating the radical cure of the operation and predicting the prognosis.
    A possibility could be suggested that the prognosis of an operation can be made with the pre-operative CEA values.
    The CEA levels in liver metastasis were higher than those, in local recurrence and in dissemination, but in more than 20ng/ml liver metastasis showed multiple. It was difficult to diagnose the solitay hepatic metastasis by the CEA values.
    A correlation could be noted between the therapeutic difficacy by the chemotherapy and the progress in the CEA values.
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  • A. Nagasaki, K. Ikeda, S. Suita, Y. Hayashida, S. Goto, K. Sumitomo
    1982 Volume 35 Issue 2 Pages 147-152
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
    Of 36 children with Hirschsprung's disease who were examined during past 5 years, 12 cases showed decrease of anal canal pressure on rectal distension.
    In most of these, technical errors were thought to be the cause of decrease of anal canal pressure such as movement of the apparatus, overdistension of rectum and overinfusion. Finally 4 cases were not diagnosed to be Hirschsprung's disease only by anorectal manometry.
    To avoid these technical errors we devised the electrical stimulation as a good method to induce recto-anal reflex. Three children who showed decrease of anal canal pressure by rectal distension did not show any decrease by electrical stimulation. Therefore, precise judgment of recto-anal reflex is necessary when anal canal pressure drops by rectal distension in the children who are suspected of Hirschsprung's disease.
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  • N. Hiwatashi, K. Kobayashi, Y. Konno, H. Watanabe
    1982 Volume 35 Issue 2 Pages 153-156
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
    When early cancer of the colon and rectum is defined as in early gastric cancer, i, e., invasion is limited to the mucosa and submucosa, biopsy specimens of 45 lesions from 44 patients with early cancer of the colon and rectum were obtained by forceps during the last 22 years. Positive findings for cancer were found in 31 of 45 lesions (69%). Most of the lesions without positive findings were small polyps 9 mm or less in diameter and Ip with cancer limited to the mucosa. Seven percent of neoplastic polyps 9 mm or less in diameter, polypectomized endoscopically, were detected as early cancer and they constituted about a third of all early cancers diagnosed by endoscopic polypectomy.
    Consequently, this study suggests that forceps biopsy is an incomplete method for the diagnosis of early cancer and endoscopic polypectomy is necessary to detect early cancer, even if polyps are 9 mm or less in diameter. We think that the value of forceps biopsy for the diagnosis of early cancer is limited with regard to both making a definitive diagnosis of Ila+Ilc and decisions on whether flat polyps, which cannot be polypectomized endoscopically, are neoplastic or not.
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  • S. Maetani, T. Nishikawa, Y. Iijma, H. Takasan, T. Tobe
    1982 Volume 35 Issue 2 Pages 157-160
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
    A case of diffuse tubulovillous adenomas of the lower rectum was reported. The treatment consisted of subsacral trans-sphincteric sleeve resection of the mucosa with endto-end anastomosis. The resected mucosa was 6 cm wide with its lower end 5 mm proximal to the dentate line and its upper end 2 cm proximal to the sacrococcigeal joint. To approximate the remaining mucosal edges, the rectum was mobilized from the sacral concavity, and the proximal mucosal margin was circumferentially dissected from the muscular coat, forming a 3 cm wide cuff while the denuded muscular tube was longitudinally plicated.
    Postoperatively, the anal continency was completely recovered. Anorectal manometry, however, showed absence of rectosphincteric reflex while the high pressure zone remained in the anal canal.
    This procedure proved to be the treatment of choice for diffuse neoplastic lesions limited to the rectal mucosa. Besides, it provided some clue as to what is essential for the anal continency.
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  • S. Watanabe, K. Arakawa
    1982 Volume 35 Issue 2 Pages 161-166
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
    During the ten years period from 1671-1980 five patients with giant villous tumors of the rectum were surgically treated. So-called villous tumors consists of various histopathological patterns, for example, of benign inflammatory lesions, tubular adenomas, villous adenomass and villous carcinomas, though their clinical signs and symptoms, laboratory findigs, X-ray and proctoscopic features are almost same in the present series. Within one villlous tumor, we often observe two or three different histological components thus sometimes we can not give the correct diagnosis preoperatively.
    Villous tumor of the rectum is rare in Japan, but their malignant change has been reported not infrequently. If a villous tumor is found, we should totally execise it and the specimen must be carefully examined. Then we should decide a plan for further treatment.
    Macroscopic giant villous tumors should be treated as an established clinical entity of colonic tumors.
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  • 1982 Volume 35 Issue 2 Pages 167-174
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
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  • 1982 Volume 35 Issue 2 Pages 175-193
    Published: 1982
    Released on J-STAGE: June 05, 2009
    JOURNAL FREE ACCESS
    Download PDF (1686K)
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