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Volume 47, Issue 3
Displaying 1-12 of 12 articles from this issue
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Especially the Expression of Tumor Necrosis Factor-α and Interferon-γ m-RNAK. Watanabe, H. Masuda1994 Volume 47 Issue 3 Pages 207-214
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSCytokines are considered to play an important role in the cause and pathogenesis of ulcerative colitis. The expression of m-RNA of cytokines including tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin-2 (IL-2) and interleukin-6 (IL-6) on the intestinal epithelium of patients with ulcerative colitis was studied using reverse transcription-coupled polymerase chain reaction (RT-PCR). Patients in this study included 16 cases with ulcerative colitis (7 cases with active phase and 9 cases with remission phase). The control group consisted of 17 cases without the large intestine disease. The following results were obtained. (1) The expression of m-RNA of TNF-α and IFN-γ in patients with ulcerative colitis was significantly higher than the control group (p<0.01, p<0.05). Regarding the expression of m-RNA of IL-2 and IL-6, no significant difference was noted between the group with ulcerative colitis and the control group. (2) In patients with ulcerative colitis, the expression of m-RNA of TNF-α and IFN-γ was not related to the degree of inflammation. (3) In terms of the expression of m-RNA of TNF-α and IFN-γ, no significant difference was found between the active phase and the phase remission. In conclusion, the expression of m-RNA of TNF-α and IFN-γ on the intestinal epithelium of cases with ulcerative colitis were enhanced irrespective of the degree of inflammation or the clinical phase. Therefore, we think that the direct tissue destruction by these cytokines (TNF-α and IFN-γ) or the indirect tissue destruction through the inducement of adhesive factors or through the activation of the lymphocyte probably triggers the cause and pathogenesis of ulcerative colitis.View full abstractDownload PDF (1424K) -
S. Osawa1994 Volume 47 Issue 3 Pages 215-223
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSEffect of a BCG nucleic acid fraction (MY-1) on prevention of liver metastases were studied in mice.
Murine colon adenocarcinoma 26 cells (1×104) were inoculated into the portal vein of female BALB/c mice. After tumor inoculation 300μg of MY-1 was injected every other day, dividing these mice into two groups depending on injection points, namely, one was injected MY-1 into spleen once and then subcutaneously 6 times (IS group, n=21) and the other subcutaneously 7 times (SC group, n=22). Half of the mice was sacrificed 21 days after inoculation, the number of metastatic nodules was significantly reduced in both IS (32±7, SE) and SC (45±9) as compared to control (111±7). Also the survival time of mice was significantly improved. To investigate the mechanism of the antitumor effects, Winn assay was done by using spleen cells. Nonadherent cells showed strong activity, and it was abolished when the spleen cells were pretreated with anti-L 3 T 4 or anti-Lyt 2 antibody and complement. These results demonstrated perioperative immunoactivation with MY-1 reducing the development of liver metastases in mice and antitumor activity was mainly ascribed to T cell activation in the spleen.View full abstractDownload PDF (1446K) -
M. Uchiyama, Y. Kubota, T. Sawada, N. Tsuno, T. Muto1994 Volume 47 Issue 3 Pages 224-233
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSThe normal distribution of the lamina propria nerve fibers in colonic mucosa and its alterations in colonic cancer stroma and transitional mucosa were studied immunohistochemically, paying special attention to the vasoactive intestinal peptide (VIP) -containing fibers.
Thirty-one colonic specimens (cancer and non-cancer) were stained for the analysis of mucin composition (HID-AB staining), and lamina propria nerve fibers (VIP and S-100 protein staining). The length of the glands and that of the lamina propria nerve fibers containing S-100 protein and VIP were quantitatively analyzed in the Auto Image Analyzer (Olympus, Japan), in normal and transitional mucosa.
In normal colonic mucosa, nerve fibers containing VIP and S-100 protein decreased progressively from the proximal to the distal colon, with a statistically significant difference between the right and left colons. Moreover, in transitional mucosa, compared to normal mucosa, there was a significant decrease in both the VIP-containing nerve fibers (2505 vs 9175μm / mm2) and S-100 protein-containing ones (4364 vs 12179 μm / mm2).
We concluded that transitional mucosa has an altered nerve fiber composition, that may be responsible for the alterations in morphology and mucin composition found in these tissues.View full abstractDownload PDF (3587K) -
K. Yoshida, M. Suzuki, K. Watanabe, Y. Inoue, K. Kameyama, Y. Takayana ...1994 Volume 47 Issue 3 Pages 234-239
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSWe studied the clinicopathological characteristics of 16 patients with diffusely invasive colorectal cancer, which accounts for 0.7% of all colorectal cancer. There were nine males and seven females with a mean age of 49 years. Five patients had moderately differentiated adenocarcinoma, five had poorly differentiated adenocarcinoma, and six had mucoid carcinoma. The depth of invasion was at least s (a2) in all cases. Severe lymphatic invasion of at least ly2 was found in 13 cases (81%). The progression of the tumor was classified into two patterns. Mucoid carcinoma or poorly differentiated adenocarcinoma did not show mucosal ulceration but showed diffuse spread below the submucosal layer. Whereas moderately differentiated adenocarcinoma showed small mucosal ulcers and massive lymphatic invasion. Of the 16 patients, 11 patients were classified Stage 4 or Stage 5. Curability was 25 %. Seven patients had recurrent tumor in the liver, 3 patients had peritonized dissemination, 2 patients had local recurrence. Among the 4 patients who had curative resection, 1 patient survived for over 5 years, 1 patient survived for over 2 years, 1 patient died of local recurrence 3 years later, and 1 patient died of a cause later unrelated to the disease 15 months.View full abstractDownload PDF (1953K) -
Y. Konuma, H. Saito, R. Uno, J. Sakamoto, H. Higashino, H. Nakajima, A ...1994 Volume 47 Issue 3 Pages 240-246
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA 68-year-old female admitted to our hospital with complaints of constipation and dysphagia. X-ray of abdomen revealed massive gas in the left abdomen, but no niveau. Barium enema showed stenosis in the rectum at 1.5cm from the anus with the dilatation proximal to the stenosis. Colonoscopy revealed rectal stenosis but normal mucosa and biopsy showed no existence of malignancy, amyloidosis, fibrosis, and inflammation. Esop hageal manometry showed high lower esophageal sphincter pressure like achalasia, and colonic manometry showed positive rectoanal reflex. She showed contracted pupil on admission, neurological examination showed she had autonomic nervous system disorder and sensory neuropathy. Cisapride and other drugs had no effect on her symptoms. In order to alleviate her symptom and obtain whole layer biopsy, transverse-anostomy was done. Surgical specimens showed gradual degenerated ganglion cells of Auerbach's and Meissner's plexus, but no aganglionosis. She had no past history of trauma, surgical operation, foreign tour, and no abnormal laboratory data. Ganglion cells of Auerbach's plexus were degenerated but aganglionosis and rectoanal reflex was positive. We diagnosed her disease as a rare case of idiopathic megacolon with neurological abnormal findings which has not been reported.View full abstractDownload PDF (4341K) -
S. Yamamoto, N. Kunimatsu, T. Kamiya, K. Suzuki, T. Yamazaki, T. Ehira ...1994 Volume 47 Issue 3 Pages 247-251
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSA rectal carcinoid after punch biopsy was transanally extirpated with the help of a "marking clip" device because of the suspected remnant lesion. The patient was a 52-year-old male with a yellowish elevated lesion measuring 4 mm in the rectum, which was colonoscopically detected. The lesion was diagnosed as carcinoid by punch biopsy, and was reexamined 2 weeks later, obtaining the pathological report of no remnant carcinoid. However, there remained the yellowish lesion surrounding the biopsy scar which strongly suspected the remnant of the carcinoid. Therefore 6 weeks after its detecion, transanal resection of the involved site was done with the marking clips left in place around the lesion prior to the operation.
Microscopic examination of the specimen revealed that the 4 mm-sized remnant carcinoid in the submucosa was not invading the proper muscle layer without definite lymphatic or vascular permeation. The remainig lesion was so minute as 4 mm in maximum diameter, that preoperative endoscopic placement of "marking clips" played a vital role in recognizing this equivocal lesion under direct vision.View full abstractDownload PDF (1420K) -
K. Taniwaka, S. Kubo, H. Ishigami, H. Konishi, K. Hara, J. Tomiyama, T ...1994 Volume 47 Issue 3 Pages 252-258
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSWe reported a case of FAP associated with colorectal and gastric cancer. A 58-year-old male was admitted to our hospital with chief complaints of constipation and anemia. Endoscopy of the upper and lower gastrointinal tracts revealed synchronous advanced cancer both in the rectum and stomach.
Due to the diagnosis of double cancer in the rectum and stomach, he underwent pelvic exenteration (since direct invasion to the urine bladder was suspected) and subtotal gastrectomy. Then the resected specimen had multiple polyps in the colorectal lesion, so we additionally conducted total colectomy under the correct diagnosis of FAP.
Histological examination revealed FAP associated with an invasive rectal carcinoma with multiple neoplastic changes in colorectal adenomas and an adovanced gastric carcinoma in the antrum of the stomach.View full abstractDownload PDF (2607K) -
M. Shinkai, T. Ichihara, T. Urakawa, J. Shirono, H. Kuroda, Y. Nishio, ...1994 Volume 47 Issue 3 Pages 259-263
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSWe have experienced a case of appendiceal mutinous cystadenoma with high level CEA in serum.
A 84-year-old man was admitted to our hospital for a right abdominal tumor.
A barium enema and barium meal study showed a tumor with smooth surface depressing the cecal wall. And the appendix was not seen. Abdominal CT and US examination showed a cystic lesion in the ileocecal region, which was diagnosed as append icecal mutinous cystadenocartinoma by elevated serum CEA level (71.9 ng /ml) preoperativ ely.
Righ hemicolectomy was performed.
Pathologically, it was diagnosed as mutinous cystadenoma with no possibility of malignancy. Immunohistological staining for CEA reveled that it was positive in the cyst wall. After the operation, negative-conversion of CEA was noted, and the patient was discharged from the hospital.View full abstractDownload PDF (3002K) -
N. Otani, I. Sasaki, Y. Funayama, H. Naito, Y. Kamiyama, C. Shibata, S ...1994 Volume 47 Issue 3 Pages 264-269
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSPyoderma gangrenosum (PG) is a rare extracolonic complication of inflammatory bowel disease (IBD), and is known as a complication difficult to manage. Here are three patients with such a complication.
Case 1. …… A 55-year-old man with ulcerative colitis underwent restorative proctocolectomy. PG on bilateral legs improved postoperatively.
Case 2. …… A 40-year-old woman with severe ulcerative colitis manifested parastomal ulceration after total proctocolectomy and continent ileostomy. Initial treatment with local stoma care failed to improve the ulceration. The ulceration resolved quickly by systemic medication of prednisolone.
Case 3. …… A 52-year-old woman with Crohn's disease had PG on the lower limbs. The lesions improved by topical application of corticosteroids.
Three patients with PG were treated successfully with surgical, medical or topical treatment.View full abstractDownload PDF (2894K) -
Y. Hattori1994 Volume 47 Issue 3 Pages 270-274
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSEarly carcinoma of the large bowel rarely metastasizes to the liver. Recently, the author has experienced a patient who had early carcinoma of the sigmoid colon metastasizing to the liver six months after sigmoidectomy. The patient was a 78-year-old female with positive occult stool. Colonoscopy detected a is-type protruding lesion in the sigmoid colon. Histological examination of the tumor tissue revealed carcinoma. Sigmoidectomy was performed, and the tumor was histologically diagnosed as submucosal carcinoma with lymphatic invasion. At six months after sigmoidectomy, CT scanning demonstrated multiple liver metastasis. She died of liver metastasis two years after sigmoidectomy. This case suggests that CT scanning and ultrasonography of the liver are necessary in patients with submucosal carcinoma of the large bowel.View full abstractDownload PDF (3818K) -
A Review of 26 Cases in JapanH. Sato, M. Maruta, J. Kuromizu, Y. Miyajima, T. Utumi, K. Toyama, K. ...1994 Volume 47 Issue 3 Pages 275-281
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSGoblet cell carcinoid of the appendix is a relatively rare neoplasma that has histologic features of both carcinoid and adenocarcinoma. We experienced a case with goblet cell carcinoid, in the appendix of the specimen that had ileocecal resection, diagnosed as mutinous cystadenoma of the cecum. The total number of the cases of goblet cell carcinoid of the appendix which had been reported in Japan was 26. In this report, we describe a woman with goblet cell carcinoid of the appendix. A 65-year-old female was admitted complaining of positive occult blood in stool, which was diagnosed as cystadenoma of the cecum. I leocecal resection was carried out. We found the goblet cell carcinoid in the appendix. In most of the 26 cases in Japan, appendectomy was performed under a diagnosis of acute appendicitis, and goblet cell carcinoid was found in the resected appendices after surgery. In five of the 26 cases in Japan, metastasis was found during surgery or recurrence was noticed after surgery and it was shown that goblet cell carcinoid of the appendix was potentially malignant. In our case, there were no symptoms before surgery, no metastasis of the liver and lymph node during surgey, and no recurrence 2 years and 7 months after surgery. It is interesting that goblet cell carcinoid in the head of the appendix produced much mucin and mutinous cystadenoma in the neck of the appendix was found discontinuously.View full abstractDownload PDF (3197K) -
1994 Volume 47 Issue 3 Pages 282-294
Published: 1994
Released on J-STAGE: June 05, 2009
JOURNAL FREE ACCESSDownload PDF (1079K)
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