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Volume 52, Issue 3
Displaying 1-11 of 11 articles from this issue
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M. Katada, Y Sugiyama, K. Kunieda, S. Saji, S. Watanabe, K. Watanabe1999 Volume 52 Issue 3 Pages 193-199
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSThe expression of mutant p53 and labeling index of proliferating cell nuclear antigen (PCNA LI) in a total of 174 colorectal tubular adenomas from 109 patients were investigated by Immunohistochemical staining and their relations with clinicopathological features were analyzed. PCNA LI and the positive rate of expression of mutant p53 increased in proportion to the degree of atypia of adenoma and were highest in early colorectal cancer. In terms of tumors size, the positive rate of expression of p53 and PCNA LI were significantly higher in tubular adenomas, being more than 6mm. In addition, the positive rate of expression of p53 and PCNA LI in tumors in the shape of Isp and Ip were significantly higher as compared with Is. these findings indicated that multiple tubular adenomas with more than moderate atypia, being over 6mm, and with peduncle, should have high malignant potential. Meanwhile, it was thought that the tubular adenoma with both positive expression of mutant p53 and high PCNA LI might be a resultant lesion of accumulation of oncogene mutations even though its size is less than 6 mm.View full abstractDownload PDF (3304K) -
K. Katsumata, K. Yamamoto, A. Murano, S. Yamashita, R. Moriwaki, K. Og ...1999 Volume 52 Issue 3 Pages 200-207
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSThe relationship of metastasis of colorectal cancers with adhesion molecules, including sialy Lea (SLA) and ICAM-1, 11-dehydro-Thromboxane B2 (11-DTXB2), which was measured as an indicator of platelet agggregation, and laminin, which was immunohistochemically determined in 108 cases with colorectal cancers, was examined. SLA in the cases with hepatic metastasis significantly increased in the cases of Hl and H2 metastases than in Dukes C cases (p<0.05). ICAM-1 did not increase in the cases of H1 and H2 metastases, but significantly increased in the cases of H3 metastasis than in Dukes C cases (p<0.05). 11-DTXB2 significantly increased in the Dukes D cases than in Dukes C cases (p<0.05). LN activity of 10 % was detected in 58.3 % of the Dukes A cases and 100 % of the Dukes D cases. LN activity of 20 % was not found in Dukes A cases, but was found in 58.3 % of the Dukes D cases. These results indicated that LN-positive cases tend to have liver metastasis.
LN activity appeared in an early stage of colon cancer. SLA was expressed in H1 and H2 metastasis ICAM-1 was expressed in H3 metastasis. 11-DTXB2 significantly increased in Dukes D.
In conclusion, adhesion molecules seem to play various biological roles in each stage of hepatic metastasis of colorectal cancer.View full abstractDownload PDF (839K) -
In Terms of IL6 Concentration in Serum and Operative FieldC. Ueno, M. Kinoshita, T. Yamamoto, S. Ono, T. Ichikura, H. Mochizuki1999 Volume 52 Issue 3 Pages 208-213
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSThe concentration of postoperative IL6 in the surgical field (local exudate from drain) and systemic circulation (Peripheral blood) in patients undergoing colorectal surgery were examined and compared with those in patients undergoing other abdominal surgeries.
Objects were total pelvic exentration : TPE group (n=4), total colectomy : IAA group (n=5), sigmoid colectomy : C group (n=5). esophagectomy : E group (n=5), pancreatoduodenectomy : PD group (n=5), total gastrectomy : G group (n6)
In all groups, the IL6 levels in the surgical field were 50 times more than those of systemic IL6 levels. There was a significant relationship between the IL6 levels in the surgical field and systemic circulation on the first postoperative day. (r=0.58. p<0.01)
The IL6 levels in the surgical field in TPE and C group was lower than those in E, PD, G, and IAA groups.
The systemic IL6 levels in TPE and C group were significantly lower than those in E and PD groups (p<0.05), and tended to be lower than those in IAA and G groups.
These results indicated that the production of IL6 in the surgical field in colorectal surgery (lower abdominal surgery) was less than that in upper abdominal surgery, and this characteristic of IL6 production might reflect the systemic IL6 levels after surgery.View full abstractDownload PDF (905K) -
I. Takemasa, N. Kikkawa, I. Nishisho, H. Mishima, M. Takeda1999 Volume 52 Issue 3 Pages 214-221
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSColorectal cancer (CRC) infiltrating the proper muscle (mp cancer) represent an intermediate stage of development from early to advanced cancer, and mp cancer is appropriate to evaluate the growth pattern of CRC. A total of 291 mp cancers accounted for 11.2 % of all CRC in this study was evaluated. mp cancers were classified into the following five types according to their gross appearance and pathological findings. They were type A : laterally spreading, type B : protruded, type C : flat elevated with central slight depression, type D concave with circumferential marginal elevation, and type E : pure depressed with no marginal elevation. The number of type A, B, C, D, and E were 47 cases (16.6 %), 76 cases (26.4 %), 46 cases (16.2 %), 110 cases (37.5 %), and 11 cases (3.7 %), respectively. Each type showed different biological behavior in the mean diameter and in incidence of lymph node metastasis, suggesting that each has a different pathway from early to advanced cancer. The new classification of mp cancer was useful to evaluate the natural history of CRC, and 23 to 30 of mp cancer might not develop via the adenoma-carcinoma sequence.View full abstractDownload PDF (6194K) -
T. Okuyama, T. Yanagida, M. Oya, S. Akao, H. Ishikawa1999 Volume 52 Issue 3 Pages 222-228
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSTo explore the relationship between cellular atypia of carcinoma and growth pattern and other pathological findings, 40 lesions of colorectal carcinomas invading to the submucosal layer were studied. Cellular atypias of both superficial and deep portions of carcinomas were separately examined. Cellular atypia was graded as low grade (L) or high-grade (H). Growth patterns of carcinomas were classified as polypoid growth (PG) type, non-polypoid growth (NPG) type, or intermediate (INT) type. Invasion patterns of carcinomas were assessed with regard to the presence of budding and the forms of residual musclaris mucosae within the tumor. Cellular atypia of the superficial portion coincided with that of the deep portion in 32 (80 %) lesions. Carcinomas with H cellular atypia in the superficial portion invaded more deeply, had lymphatic invasion more frequently, were mainly INT or NPG type, and showed budding in the deep portion more frequently. Therefore, carcinomas with H cellular atypia in superficial portions a pear to have greater malignant potential than those with L cellular atyia in that portion.View full abstractDownload PDF (6218K) -
Amelanotic and Hypomelanotic Malignant MelanomaY. Suzuki, M. Oumi, M. Takahasi, T. Isomatu, T. Kawakami1999 Volume 52 Issue 3 Pages 229-234
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSTwo cases of malignant melanoma of the rectoperineal region, which is relatively rare, were reported. Case 1, a 57-year-old female visited our hospital with anal pain on defecation. A polypoid tumor was found in the rectum but making the diagnosis was difficult because of amelanotic melanoma. She died of multiple metastasis (liver, lymph node, bone, and abdomen) 1 year 7 months after radical operation.
Case 2, a 46-year-old female visited our hospital complaining of anal pain. on the operation, peritoneal dissemination was found. She died of brain and adrenal metastases 7 months after operation. The tumor was about 6cm in diameter and diagnosed as hypomelanotic malignant melanoma.
This disease develops lymphatic and hematogenic metastasis rapidly. Early diagnosis and early treatment are important.View full abstractDownload PDF (6006K) -
S. Kimura, K. Suzuki, T. Aizawa, H. Kanazawa, M. Tanaka1999 Volume 52 Issue 3 Pages 235-241
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSA 66-year-old male was admitted to our hospital and underwent surgical treatment in April, 1996 because of 4 synchronous primary tumors of the gastrointestinal tract. Apart from the above tumors preoperative colonoscopy and barium enema disclosed several yellow-white intramural tumors less than 10 mm in diameter located in the sigmoid colon 25-50 cm from the anus. One of these lesions was endoscopically resected and histological examination revealed a tumor-like massive AL type amyloid deposit in the submucosal layer. However, subsequent extensive examinations failed to find any amyloid deposits in other parts of the gastrointestinal tract or any apparent signs of systemic amyloidosis. The diagnosis of amyloid tumors of the left colon was made, and these tumors were followed up for 25 months. Although the number of the tumors has slightly increased from 7 to 9 and the size of the largest tumor among the lesions was 15 mm, a significant change was not recognized during the course of observation. The oral margin of the lesions did not extend beyond the splenic flexure. Repeated examinations could not demonstrate any other separate amyloid deposits in the gastrointestinal tract. This case suggested slow progress and mild development in the natural course of colonic amyloid tumors.View full abstractDownload PDF (5288K) -
T. Nishio1999 Volume 52 Issue 3 Pages 242-246
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSA case of Leiomyosarcoma of the mesosigmoid with rapid general metastasis is reported. A 62-year-old male with a one-month history of abdominal discomfort, constipation, and nausea was investigated with CT scan and barium enema. The CT scan of the abdomen showed a solitary tumor 10 cm in diameter in the lower left abdomen, and the CT scan of chest showed bilateral multiple metastasis. Sigmoidectomy was performed. The tumor was 8.5×9.0×8.0 cm in size, and was diagnosed histopathologically as Leiomyosarcoma of the mesosigmoid. Bone metastasis to thoracic vertebrae was discovered 7 months after the initial operation. The patient died 10 months after complaining of abdominal discomfort, constipation, and nausea in spite of chemotherapy. Mesocolonal Leiomyosarcoma is a rare entity and only 19 cases have been reported in japan. The 5-year cumulative survival rate after operation was 49.2 %, but our patient died 10 months after the initial complaint because the tumor had a high cell growth rate.View full abstractDownload PDF (5766K) -
O. Ishihara, M. Maruta, K. Maeda, T. Utsumi, K. Toyama, H. Sato, Okum ...1999 Volume 52 Issue 3 Pages 247-252
Published: 1999
Released on J-STAGE: February 05, 2010
JOURNAL FREE ACCESSFour cases of colorectal cancer with solitary adrenal grand tumor were retrospectively studied as to whether or not preoperative differential diagnosis between metastatic and benign condition is possible. The mean age of the patients was 54.8 years old, and the male to female ratio was 1 to 1. Three cases had rectal cancer and one sigmoid colon cancer. All adrenal tumors were found by computed tomography (CT) of the abdomen. One tumor was located in the left adrenal grand, and the others on the right side. Two tumors were found preoperatively, the others postoperatively.
The maximum diameter of tumors were three to four centimeters. Magnetic resonance imaging (MRI) of the abdomen was performed in two cases, and angiography in one case. The level of serum CEA was within the normal range in all cases, but that of serum CA19-9 was out of the normal range in two cases. Endocrinary function test revealed that all tumor were nonfunctional. Adrenalectomy was performed in all cases in suspicious metastatic adrenal tumor. Histopathological examinations showed that three of the tumors were adenomas, and one metastatic adenocarcinoma.
It was considered to be difficult to distinguish adenoma from metastatic tumor by preoperative findings.View full abstractDownload PDF (6693K) -
[in Japanese], [in Japanese]1999 Volume 52 Issue 3 Pages 253-254
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSDownload PDF (3767K) -
1999 Volume 52 Issue 3 Pages 255-291
Published: 1999
Released on J-STAGE: October 16, 2009
JOURNAL FREE ACCESSDownload PDF (6547K)
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